# Core B - Cryo-Electron Microscopy  Core

> **NIH NIH P01** · TEXAS A&M AGRILIFE RESEARCH · 2021 · $266,783

## Abstract

Project Summary – Core B – Cryo-Electron Microscopy Core
The TBSGC will expand its capabilities in structural biology by incorporating cryo-electron microscopy
(cryo-EM) as a means to study the structures of proteins that are either not amenable to crystallography,
or importantly when crystallography and cryo-EM can be used to “combine” component x-ray structures
into large macromolecular complexes. Recent advances in single-particle cryo-electron microscopy
(cryo-EM) have enabled the structure determination of large macromolecular complexes to atomic
resolution. This breakthrough is mostly attributed to the development of the instrumentation needed to
acquire better images and the software to more reliably process and validate the results. This is especially
true for very large protein complexes, like the ribosome, as well as membrane proteins. The core lab at
Texas A&M has state of the art instrumentation and expertise through Dr. Junjie Zhang’s group. Dr.
Zhang will use the Texas A&M EM facility which is a fully staffed laboratory for help with administrative
aspects and even some of the sample preparation and data collection for core samples.

## Key facts

- **NIH application ID:** 10242861
- **Project number:** 5P01AI095208-08
- **Recipient organization:** TEXAS A&M AGRILIFE RESEARCH
- **Principal Investigator:** Junjie Zhang
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $266,783
- **Award type:** 5
- **Project period:** 2012-09-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10242861

## Citation

> US National Institutes of Health, RePORTER application 10242861, Core B - Cryo-Electron Microscopy  Core (5P01AI095208-08). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10242861. Licensed CC0.

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