# Project 2 - TB Translation as a Target

> **NIH NIH P01** · TEXAS A&M AGRILIFE RESEARCH · 2021 · $502,618

## Abstract

Translation plays a key role in the survival of any cell and is a hub for many regulatory pathways that
control cellular growth. Due to this complexity, the ribosome has proven to be a vulnerable antibiotic
target and several existing antituberculous compounds block translation. We have capitalized on recent
advances in cryo-EM techniques to explore the unique structural aspects of the mycobacterial ribosome
that might alter antimicrobial efficacy and be exploited by new therapeutics.

## Key facts

- **NIH application ID:** 10242864
- **Project number:** 5P01AI095208-08
- **Recipient organization:** TEXAS A&M AGRILIFE RESEARCH
- **Principal Investigator:** JAMES C SACCHETTINI
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $502,618
- **Award type:** 5
- **Project period:** 2012-09-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10242864

## Citation

> US National Institutes of Health, RePORTER application 10242864, Project 2 - TB Translation as a Target (5P01AI095208-08). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10242864. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*