# Personalizing EmerGency/Acute therapeuticS Utilizing Systems biology (PEGASUS)

> **NIH NIH R35** · UNIVERSITY OF COLORADO DENVER · 2021 · $388,750

## Abstract

Abstract
The global objective of the Personalizing EmerGency/Acute therapeuticS Utilizing Systems biology
(PEGASUS) Research Program is to improve drug effectiveness and safety in common acute care conditions.
Drug therapy for acute conditions in the emergency department is only effective in 25-60% of cases. There is
tremendous opportunity to improve acute therapeutics by implementing precision medicine programs in acute
care settings. We will use phenotypic data from our electronic health record and link this data to
pharmacogenomic and metabolomic data to discover new mechanisms of drug effectiveness and safety.
Ultimately clinical, genomic, and metabolomic data will be integrated into predictive systems biology models to
improve therapeutic success in acutely ill patients. The PEGASUS program is supported by the Rocky
Mountain Biorepository and the Colorado Center for Personalized Medicine. Through the Maximizing
Investigators' Research Award for Early Stage Investigators (MIRA-ESI) funding announcement PEGASUS will
focus on common acute care conditions such as nausea, pain, and cardiovascular disease with eventual
expansion to more uncommon drug safety conditions such as anaphylaxis and torsades de pointes. We utilize
polymorphism in drug metabolizing enzymes, such as CYP2D6, as the hub of our models and use the biologic
perturbations present in acute illness to identify new pathways, mechanisms, and genetic variants associated
with drug safety and effectiveness in these common conditions. In the future, these models will be tested
prospectively. Implementation of this systems biology approach to precision medicine will improve drug
effectiveness and safety in acute conditions.

## Key facts

- **NIH application ID:** 10242868
- **Project number:** 5R35GM124939-05
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Andrew Albert Monte
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $388,750
- **Award type:** 5
- **Project period:** 2017-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10242868

## Citation

> US National Institutes of Health, RePORTER application 10242868, Personalizing EmerGency/Acute therapeuticS Utilizing Systems biology (PEGASUS) (5R35GM124939-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10242868. Licensed CC0.

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