# High-throughput Latent HIV Reservoir Assay Using Microwell Arrays

> **NIH NIH N44** · CELL MICROSYSTEMS, INC. · 2020 · $1,648,645

## Abstract

The goal of this project is to design a high-throughput assay platform that can be used to reproducibly quantify changes in the size of the replication-competent latent HIV reservoir in resting CD4+ memory T cells isolated from individuals on highly effective antiretroviral therapy.  Included are studies for validating the assay by demonstrating correlation with quantitative viral outgrowth assays (QVOA) and/or functional non-induced HIV proviruses using cells isolated from virally suppressed HIV+ individuals on optimized antiretroviral therapy.

## Key facts

- **NIH application ID:** 10243454
- **Project number:** 75N93020C00050-0-9999-1
- **Recipient organization:** CELL MICROSYSTEMS, INC.
- **Principal Investigator:** JENNIFER HARTMAN
- **Activity code:** N44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,648,645
- **Award type:** —
- **Project period:** 2020-08-13 → 2022-08-12

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10243454

## Citation

> US National Institutes of Health, RePORTER application 10243454, High-throughput Latent HIV Reservoir Assay Using Microwell Arrays (75N93020C00050-0-9999-1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10243454. Licensed CC0.

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