# Translational Research in Cancer

> **NIH NIH P30** · THOMAS JEFFERSON UNIVERSITY · 2020 · $149,181

## Abstract

Overall Project Summary
The mission of the Sidney Kimmel Cancer Center (SKCC) is to leverage research expertise to reduce the overall
incidence, burden, and mortality from cancer in Greater Philadelphia and beyond. SKCC goals are realized
through unique strengths in addressing cancer problems through collaboration across basic, clinical, and
population research disciplines. As a matrixed, consortium cancer center, SKCC leverages the intellectual
strength of discoveries of members at Thomas Jefferson University (TJU), Drexel University (DU) Schools of
Medicine and Public Health, and Lankenau Institute for Medical Research (LIMR). Expertise is clustered into five
major Research Programs, two of which are Discipline-Based Programs and three of which are Disease-Oriented
Programs. A notable feature of SKCC Programs is that each is comprised of highly integrated basic, clinical, and
population researchers, working together on research areas that address the cancer-associated needs of the
catchment area. This is an intentional structure that further blossomed under the guidance of new SKCC
leadership and the revitalized External Advisory Board (EAB). Given the health research and care focus of the
parent university (TJU), this mechanism of Program integration mirrors the strong translational focus and
interdisciplinary nature of the organization. SKCC utilizes the TIPS (Transdisciplinary Integration of Population
Science) mechanism as a highly specialized, cross-cutting organizational structure that has the benefit of
allowing population scientists to remain programmatically integrated into Programs with basic and clinical
researchers, as well as providing a platform for cultivating new population oriented strategies that can be
deployed across all Programs. Thematic working groups also exist that link subspecialties across Programs, in
addition to Shared Resources that provide exceptional expertise, services, and technologies required for leading
edge investigation and high scientific impact. Under the new Director, Dr. Knudsen (appointed January 2015),
SKCC sharpened focus on addressing catchment area needs, nurtured transdisciplinary research, expanded
research capabilities, extended outreach and clinical research into the community, and enhanced the pace of
bench-to-bedside discovery. The roadmap for the SKCC mission is paved by a strategic plan deemed IMPACT,
developed by Dr. Knudsen and highly engaged SKCC Leaders. Under Dr. Knudsen’s leadership, SKCC
increased: membership, the pace and breadth of impactful discovery, bench-to-bedside translation, clinical trial
activity, cancer-focused funding, capacity to address the cancer needs of the catchment area, and the overall
impact of the Center. Current aims are to: 1) Discover the molecular basis of cancer development & progression
in diverse populations through integration of basic, population, and clinical research; 2) Develop knowledge into
effective new prevention, detection, and treatment strat...

## Key facts

- **NIH application ID:** 10243653
- **Project number:** 3P30CA056036-21S4
- **Recipient organization:** THOMAS JEFFERSON UNIVERSITY
- **Principal Investigator:** KAREN E KNUDSEN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $149,181
- **Award type:** 3
- **Project period:** 1995-06-22 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10243653

## Citation

> US National Institutes of Health, RePORTER application 10243653, Translational Research in Cancer (3P30CA056036-21S4). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10243653. Licensed CC0.

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