# Pre-clinical Assessment Core

> **NIH NIH P20** · CLEMSON UNIVERSITY · 2021 · $326,673

## Abstract

SUMMARY
The purpose of translational research is to foster and facilitate technology advancements from the basic sciences
to the clinical in vivo realm for the advancement of patient care. The Pre-Clinical Assessment Core (PAC) will
serve as a platform to facilitate the transfer of in vitro advances into clinical practice by providing the facilities
and expertise to actuate potential technologies into pre-clinical modeling. PAC is founded on Clemson
University's long history of musculoskeletal innovation research using animal models and the recently built
Clemson University Biomedical Engineering Innovation Campus (CUBEInC). PAC will consolidate these existing
research resources and expertise for the translation of innovations at Clemson University and Greenville Health
System into a comprehensive network of experts and services to be organized into two complementary thrusts:
Animal Modeling and Post-Mortem Assessment (AM-PMA) and Human Cadaveric Modeling (HCM). The AM-
PMA thrust builds on established, AAALAC-accredited, research facilities on the Clemson University main
campus that provide state-of-the-art support for animal procurement, management and experimental
studies. These include the Godley-Snell Research Center and the Clemson University Farms. Additionally,
it includes the Clemson University histotechnological facilities including state-of-the-art processing
equipment for both routine histology and hard tissue/metal processing including immunohistochemistry and
imaging. The HCM thrust builds on the established Bioskills Surgical Training and Innovation Center and
other resources at CUBEInC. The PAC leadership team will consist of the thrusts co-directors, both renowned
clinicians and scientists, as well as a support group of technical experts and scientists. The overall mission of
PAC is to provide mentoring and strategic planning to all SC-TRIMH investigators for the use of live animal
models and/or human cadaver models in their research programs to enhance their research, innovation
and competitiveness in the field of musculoskeletal health. Through PAC, SC-TRIMH investigators will learn
how to develop and implement pre-clinical studies pertinent to musculoskeletal applications and assess the
outcomes of their studies. Additionally, PAC will provide translational expertise, support and training for SC-
TRIMH investigators, as well as other PIs at Clemson University, in South Carolina, and the IDeA network.
The specific aims of the Pre-Clinical Assessment Core, a critical resource for musculoskeletal researchers, are
to 1) provide expertise and support for pre-clinical modeling with a “turnkey” approach, 2) support junior
investigator for the development of new models of pre-clinical assessment and 3) enhance the in vivo and ex
vivo pre-clinical research capability to foster an increase in awareness of the facilities, increase users focused
on musculoskeletal and support the coalescing of SC-TRIMH center. COBRE funds will support hig...

## Key facts

- **NIH application ID:** 10244918
- **Project number:** 5P20GM121342-04
- **Recipient organization:** CLEMSON UNIVERSITY
- **Principal Investigator:** Jeryl Jones
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $326,673
- **Award type:** 5
- **Project period:** 2018-09-15 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10244918

## Citation

> US National Institutes of Health, RePORTER application 10244918, Pre-clinical Assessment Core (5P20GM121342-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10244918. Licensed CC0.

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