# Biostatistics and Computational Biology Core - Core B

> **NIH NIH P50** · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $169,557

## Abstract

This Glioma SPORE will require statistical and bioinformatics collaboration on a wide variety of research,
ranging from pre-clinical models to human studies. The mission of the Biostatistics and Computational
Biology Core of this glioma SPORE is to foster rigor and reproducibility. Towards this end, the core will work
with project leaders to insure statistical integrity in the design of their experiments and interpretation of their
data. The Biostatistics and Computational Biology Core will function as a scientific hub to facilitate interand
intra- SPORE collaborations between all Projects and with the Pathology Core. The core will advise on all
issues related to data collection, analysis and interpretation. The core will provide 1) ready and dedicated
resources for database and computing requirements, 2) consultation and expertise on the development and
implementation of plans for data collection, particularly the coding convention and variable format required for
statistical analysis, 3) advice on the data management plan, including form design and database requirements,
during development of the SPORE-related clinical trials, 4) expertise and resources for data transfer, merging,
sharing and security while maintaining the confidentiality of all patient-related protected health information, 5)
statistical expertise for the design, planning and conduct of preclinical experiments, clinical trials and
correlative tissue and biomarker studies, 6) analysis of the clinical trials and interim monitoring and analysis, if
necessary, including the stopping rules for safety and futility, 7) statistical and bioinformatics expertise for
inference and interpretation of research studies, including manuscript preparation.

## Key facts

- **NIH application ID:** 10245091
- **Project number:** 5P50CA165962-08
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Steven Piantadosi
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $169,557
- **Award type:** 5
- **Project period:** 2013-09-19 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10245091

## Citation

> US National Institutes of Health, RePORTER application 10245091, Biostatistics and Computational Biology Core - Core B (5P50CA165962-08). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10245091. Licensed CC0.

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