# Pathology - Core A

> **NIH NIH P50** · BRIGHAM AND WOMEN'S HOSPITAL · 2021 · $295,939

## Abstract

The overall goal of this SPORE application is to develop more effective targeted molecular therapies and
biomarkers for glioblastoma. The four proposed projects of the SPORE focus on 1) targeted therapeutics to
treat BRAF-mutant pediatric gliomas; 2) development of improved targeted therapies for IDH-mutant gliomas;
3) combining targeted CDK4/6 inhibitors with immunotherapies to treat glioblastoma; and 4) evaluation of
Nlgn3 as a novel therapeutic target in gliomas. The Pathology Core will support the goals of these SPORE
Projects by providing expert neuropathologic review, specimen banking, genomic analysis and clinical trial
support. In addition, the Pathology Core will be a centralized resource for validated patient derived cell lines
and xenografts of gliomas. The Core will also offer innovative CyTOF on a slide multiplex imaging (MIBI), mass
spectrometry imaging of drug distribution within tissue sections, and liquid biopsy of circulating tumor cells
(CTC) to determine responses to targeted therapies in clinical trials. By centralizing these activities, the
Pathology Core will ensure the reproducibility of data and effective use of finite glioma tissue resources
essential to the collaborative translational research of the SPORE program.

## Key facts

- **NIH application ID:** 10245092
- **Project number:** 5P50CA165962-08
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** KEITH LLOYD LIGON
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $295,939
- **Award type:** 5
- **Project period:** 2013-09-19 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10245092

## Citation

> US National Institutes of Health, RePORTER application 10245092, Pathology - Core A (5P50CA165962-08). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10245092. Licensed CC0.

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