# RegulomeDB: A Resource for the Human Regulome

> **NIH NIH U24** · STANFORD UNIVERSITY · 2021 · $674,483

## Abstract

PROJECT SUMMARY
The Human RegulomeDB project provides an essential resource that facilitates medical
research and exploratory investigations of gene regulation. The majority of sequence variation
identified in genome sequencing projects and disease association studies (GWAS) lie within the
98% of the human genome that is non-exomic. RegulomeDB is a unique web accessible
resource that provides integrated knowledge of the wealth of existing information concerning
regulatory elements that lie within non-exomic regions. The unique feature of this resource is its
ability to comprehensively annotate, integrate and display the experimentally defined functional
and biochemical regulatory elements of the human genome. Information generated from
individual laboratories and consortia concerning potential regulatory regions such as that
affecting gene expression, transcription factor binding, chromatin modification and DNA
methylation will be collected from the literature, and integrated into a common database and
displayed at nucleotide resolution. The information can be readily accessed via a web
accessible interface and related to sequence variations identified from large scale projects (e.g.
db SNPs, 1000 genome project, GWAS studies). Researchers will be able to compare variants
identified from personal genomes and large scale sequencing projects as well as GWAS studies
to the wealth of information in RegulomeDB, and thereby rapidly gain knowledge of non-exomic
information. Given the wealth of DNA sequencing project that are emerging, we expect this
unique resource to have wide impact in the biomedical community.

## Key facts

- **NIH application ID:** 10245271
- **Project number:** 5U24HG009293-05
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Alan P Boyle
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $674,483
- **Award type:** 5
- **Project period:** 2017-02-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10245271

## Citation

> US National Institutes of Health, RePORTER application 10245271, RegulomeDB: A Resource for the Human Regulome (5U24HG009293-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10245271. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*