# Sleep Quality and Mechanisms of Cardiovascular Risk in Adults with Hypertension

> **NIH NIH R01** · DUKE UNIVERSITY · 2021 · $757,967

## Abstract

R01 Brief Project Summary
Sleep Quality and Mechanisms of Cardiovascular Risk in Adults with Hypertension
The objective of the study is to elucidate the potential mechanisms responsible for the increased risk of CVD
among patients with hypertension and comorbid insomnia. To address this issue, we propose to utilize a
behavioral intervention to manipulate sleep quality in 150 adults with hypertension and comorbid insomnia, who
will receive a 6-week Cognitive Behavioral Therapy for Insomnia (CBT-I) intervention, which has been shown to
markedly improve sleep quality and promote consolidated sleep in approximately 60% of those treated. Blunted
nighttime blood pressure dipping is one of several proposed mechanisms to be examined.

## Key facts

- **NIH application ID:** 10246161
- **Project number:** 5R01HL148424-03
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** ANDREW SHERWOOD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $757,967
- **Award type:** 5
- **Project period:** 2019-07-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10246161

## Citation

> US National Institutes of Health, RePORTER application 10246161, Sleep Quality and Mechanisms of Cardiovascular Risk in Adults with Hypertension (5R01HL148424-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10246161. Licensed CC0.

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