# UM CFAR SCCC Argentina Consortium for research and training in Virally Induced AIDS Malignancies

> **NIH NIH U54** · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2021 · $182,631

## Abstract

Around 80% of viral cancers occur in countries with emerging economies such as LMICs. An important subset
of virally induced malignancies occurs in the context of HIV/ AIDS (AIDS associated Malignancies/ AM). Latin
America have a high prevalence of AIDS-associated Malignancies caused by viruses (including HR-HPV, EBV,
KSHV) which tend to disproportionally affect underprivileged and socially vulnerable populations. The current
consortium addresses the need of developing research strength in AIDS associated Malignancies while
developing a critical mass of independent basic, translational and clinical AIDS-malignancies researchers of
Argentina. The current U54 will focus in the career development of junior scientists belonging to an existing
consortium of UM CFAR with Argentina Labs through the development of mentored research focusing in the
general theme and cancer type of “Basic, translational and Clinical research and training network in virally-
induced AIDS-defining malignancies disproportionally affecting Argentina populations with highest risk of HIV/
AIDS”. In the case of Buenos Aires this is both the MSM population with a 11% HIV-infection incidence and the
transgender women (TGW) population with an HIV-infection incidence of 37% which are at also the highest
risk for infection with oncoviruses KSHV and HR-HPV, and to develop KS and anogenital carcinoma. It will
further develop areas emerging from highly complementary and integrated current research of the consortium
projects supported by highly tailored Career Enhancement and Shared Resources Cores that will leverage the
outstanding research, human resources and infrastructure for HIV/AIDS and viral oncology research available
at UM's CFAR, Sylvester Cancer Center, Argentina institutions and the powerful network of Argentine US
scientists in USA associated with the consortium. Its components will include an Administrative core, a career
enhancement core, a shared resource core and three projects of mentored research that will leverage and
enhance the scientific and clinical capacity of the network, generating and leveraging a repository of clinical
samples and longitudinal cohort that will enable to correlate clinical findings with molecular/genetic data.
Aim 1: To develop research capacity in AM by developing the career of a critical mass of junior researchers in
the context of shared resources and scientific networks provided by the consortium institutions. Aim 2:
research on “Viral induced AIDS-defining malignancies disproportionally affecting populations in Argentina with
the highest risk of HIV/ AIDS” to elucidate molecular and cellular mechanisms of oncogenesis, identify
therapeutic targets, prevent cancer, facilitate diagnosis and treatment. P1: Oncogenic signaling networks in
AIDS-associated viral cancers as targets of chemoprevention and treatment. P2: Molecular, viral and genetic
epidemiology of virally induced AIDS-defining cancers affecting Argentina population with highest ri...

## Key facts

- **NIH application ID:** 10246315
- **Project number:** 5U54CA221208-05
- **Recipient organization:** UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- **Principal Investigator:** Omar Adrian Coso
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $182,631
- **Award type:** 5
- **Project period:** 2017-09-20 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10246315

## Citation

> US National Institutes of Health, RePORTER application 10246315, UM CFAR SCCC Argentina Consortium for research and training in Virally Induced AIDS Malignancies (5U54CA221208-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10246315. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*