# Core 1 Oncogenomics and Bioinformatics Core (OGB)

> **NIH NIH U54** · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2021 · $29,402

## Abstract

Shared Resource Core (OGB) Summary
Human malignant neoplastic diseases have been extensively characterized by functional genomics approaches during
the past decade, allowing the identification of different cancer molecular subtypes and the development of prognostic
and predictive biomarkers. However, no studies have been reported comprehensively screening for the mutational and
transcriptomic profiles of AIDS-associated malignancies (AM). The three interrelated projects of the U54 will employ
the Next Generation Sequencing (NGS) platform to perform mutational and transcriptomics studies of AM biopsies as
well as in-vitro and in vivo tumor studies using different murine models and cancer cell lines. Detailed unraveling of the
AM genome coupled with a deeper understanding of its transcriptome and their viral associated factors will be
instrumental to understand the molecular mechanisms and pathways that govern the progression of these neoplastic
lesions.
We will create a bilateral Oncogenomics (located at UM, USA) and Bioinformatics (located at UNLP, Argentina) Core
(OGB) that will provide investigators access to resources not currently available for the Argentina Labs and centers
investigators. The bilateral OGB-Core facility will be in charge of the design, generation, pre-processing, statistical and
data mining analysis of the functional genomics data generated by the NGS platform available at OGB Core. The
genomic data and clinical data will be centralized at the core server providing unified functional genomics resources
that will serve as hub for coordinating converging approaches. Furthermore, the OGB Core will provide training to all
junior scientists, Argentina investigators from the network as well as new investigators attracted via Pilots
program offered by the U54 Consortium.

## Key facts

- **NIH application ID:** 10246317
- **Project number:** 5U54CA221208-05
- **Recipient organization:** UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- **Principal Investigator:** SION LLEWELYN WILLIAMS
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $29,402
- **Award type:** 5
- **Project period:** 2017-09-20 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10246317

## Citation

> US National Institutes of Health, RePORTER application 10246317, Core 1 Oncogenomics and Bioinformatics Core (OGB) (5U54CA221208-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10246317. Licensed CC0.

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