# Core B - Pathology and Biospecimen Core

> **NIH NIH P50** · DANA-FARBER CANCER INST · 2021 · $207,657

## Abstract

Project Summary 
The acquisition, pathologic analysis and molecular characterization of human and mouse model 
gastrointestinal (GI) samples is an integral requirement for all portions of this SPORE. This 
Core will continue to provide SPORE investigators multiple pathology services to support 
Research Projects and future Career Enhancement Program (CEP) and Developmental 
Projects (DP) awardees. We will work in close collaboration with investigators to achieve three 
crucial purposes: i) to provide tissue specimens and pathology expertise to evaluate human and 
mouse models of GI neoplasms; ii) to provide molecular pathologic expertise in state-of-the-art 
molecular evaluation of tissue specimens; and iii) to evaluate and implement new tissue and 
cellular imaging and analysis technologies that will benefit these research goals in the future. 
Centralization of Core activities builds upon established infrastructure and expertise of these 
investigators, and complements but does not replicate existing infrastructure in our Cancer 
Center and provides a valuable component to the analysis of biological resources developed 
and utilized by SPORE investigators. To bring pathology based scientific support to all SPORE 
projects, this Core proposes the following specific aims: 
Specific Aim 1: To provide human biospecimen procurement and distribution. 
Specific Aim 2: Generation of models for pre-clinical trials 
Specific Aim 3: Pathologic characterization of human and mouse GI tumors using molecular 
pathology tools and emerging new technologies

## Key facts

- **NIH application ID:** 10246347
- **Project number:** 5P50CA127003-13
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** SICINSKA
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $207,657
- **Award type:** 5
- **Project period:** 2007-04-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10246347

## Citation

> US National Institutes of Health, RePORTER application 10246347, Core B - Pathology and Biospecimen Core (5P50CA127003-13). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10246347. Licensed CC0.

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