# SPORE in Gastrointestinal Cancers

> **NIH NIH P50** · JOHNS HOPKINS UNIVERSITY · 2021 · $2,273,000

## Abstract

This application for continuation of the Specialized Program of Research Excellence (SPORE) in
Gastrointestinal Cancer at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins supports a
highly interactive, multidisciplinary program. Four research projects, four cores, a career development and a
research developmental program are proposed to extend our translational research in colorectal and
pancreatic cancer.
Project 1, Improving Pancreatic Cancer Risk Assessment: Clinical/Population Leader Dr. Alison Klein and
Basic Science Leader Dr. Michael Goggins.
Project 2, Neo-antigen Vaccines for Pancreatic Cancer and Colorectal Cancer. Basic Science Leaders
Drs. Elizabeth Jaffee and Drew Pardoll and Clinical Leaders Drs. Daniel Laheru and Nilo Azad.
Project 3, Diagnosis and Management of Pancreatic Cysts: Clinical Leader Dr. Anne Marie Lennon and
Basic Science Leaders Drs. Ken Kinzler and Bert Vogelstein
Project 4, Using TME genetics and immunobiology to drive combination immunotherapies. Basic
Science Leader Dr. Elizabeth Jaffee and Clinical Leaders: Drs. Dung Le and Lei Zheng
The cores support the research programs (Admin Core: Administration and Communication, Dr. Alison Klein;
Core 1, Statistics/Bioinformatics, Drs. Elizabeth Sugar and Robert Scharpf: Core 2, Human Tissue Research
and Logistics, Dr. Robert Anders; Core 3, Familial and Population Cancer Registries, Drs. Frank Giardiello and
Alison Klein.
The Career Development Program (Dr. Scott Kern) aids the emergence of new investigators and the Research
Developmental Program (Dr. Bert Vogelstein) provides rapid funding of innovative directions

## Key facts

- **NIH application ID:** 10246361
- **Project number:** 5P50CA062924-27
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Alison P Klein
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $2,273,000
- **Award type:** 5
- **Project period:** 1997-02-28 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10246361

## Citation

> US National Institutes of Health, RePORTER application 10246361, SPORE in Gastrointestinal Cancers (5P50CA062924-27). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10246361. Licensed CC0.

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