# Research Core

> **NIH NIH P20** · LAUREATE INSTITUTE FOR BRAIN RESEARCH · 2021 · $655,326

## Abstract

Project Summary 
The Research Core of Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) will 
provide the scientific infrastructure that supports all projects. The Research Core will utilize the Research 
Domain Criteria (RDoC) framework to provide a multilevel assessment, intervention, and analysis that cut 
across all projects consisting of assays for cells and molecules, circuits & physiology, symptoms & behavior, 
and a standardized intervention for longitudinal prediction as well as bioinformatics to apply sophisticated 
statistical approaches to generate clinically meaningful predictions. The multi-level assessment provided by the 
Research Core will focus on three domains: (a) positive valence (systems that support “what makes us feel 
good”), (b) negative valence (systems that support “what makes us feel bad”), and (c) interoception and 
arousal (systems that underlie the “brain body connection”). Experienced investigators, who have developed a 
standardized pathway of acquiring and analyzing, will lead the components: (a) Cells and Molecules, i.e. 
standardized bioassays; (b) Circuits & Physiology, i.e. multimodal imaging by combining EEG and fMRI; (c) 
Symptoms & Behavior, i.e. standardized recruitment using PhenX measures and the NIH PROMIS system, 
and (d) Intervention, i.e. using a well-validated exposure and behavioral activation therapy. The Research 
Core will support the projects that will use a neuroscience-based multi-level assessment approach to (1) 
delineate the neural processing dysfunctions in individuals with mood, anxiety, and eating disorders, and (2) 
utilize these measures to predict clinically meaningful outcomes. This Core will provide the bioinformatics for 
the cross-sectional phase of the NeuroMAP investigator projects (Year 1-3) and apply machine-learning tools 
to generate predictions at a single subject level for the longitudinal phase of the projects (Year 3-5). The 
specific aims are: (1) To provide a standardized multi-level assessment procedure for all NeuroMAP projects. 
(2) To support all NeuroMAP research infrastructure. (3) To create a trans-project repository of multi-level data. 
Creating a Research Core strikes a reasonable balance between centralizing most, but not all, assessment 
procedures. The NeuroMAP investigators are able to develop and utilize assessments that are germane to the 
specific project, but also rely on standardized procedures for the core domains. By pooling subjects across 
projects who have undergone standardized multilevel baseline assessments one can conduct secondary 
analyses of individual differences in individuals with mood, anxiety and eating disorders that may help to guide 
future research projects. In particular, this database will allow young investigators, e.g. postdoctoral fellows, 
associate investigators, or even graduate students, to generate new research questions and projects with 
patient populations relatively quickly and inexpensively. ...

## Key facts

- **NIH application ID:** 10246386
- **Project number:** 5P20GM121312-05
- **Recipient organization:** LAUREATE INSTITUTE FOR BRAIN RESEARCH
- **Principal Investigator:** Jerzy Aleksander Bodurka
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $655,326
- **Award type:** 5
- **Project period:** 2017-09-15 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10246386

## Citation

> US National Institutes of Health, RePORTER application 10246386, Research Core (5P20GM121312-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10246386. Licensed CC0.

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