# Proteomics Core

> **NIH NIH P30** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2021 · $59,660

## Abstract

PROJECT SUMMARY: PROTEOMICS MODULE
 The Vanderbilt Vision Research Center (VVRC) includes investigators with a strong interest in
discerning how protein signatures govern functional circuits in the visual pathways and predispose patients
towards disease and response to treatment. These relationships require the ability to measure protein content
and patterns in large numbers of samples, transgenic animals, and even within highly localized intact tissues.
The purpose of the VVRC Proteomics Module is to provide a comprehensive resource for all mass
spectrometry needs for investigators needing proteomics, metabolomics, or tissue imaging via mass
spectrometry. This module provides access to state-of-the-art mass spectrometry, proteomics, and mass
spectrometry tissue imaging facilities via subsidized scholarship use of the Vanderbilt Mass Spectrometry
Research Center (MSRC). The MSRC comprises the Mass Spectrometry Core Laboratory, the Proteomics
Laboratory, and the Tissue Imaging Core, all with bioinformatic support through the MSRC Bioinformatics
Group. VVRC support translates on a dollar-for-dollar basis to scholarships issued to VVRC investigators
applicable for all MSRC services. This scholarship system is implemented by the VUMC Office of Research
and is utilized instead of a discount or co-pay via the VUMC ILab accounting system. In the current funding
cycle, the Proteomics Service Module was used by 10 investigators who authored 86 publications using the
service and saved our investigators $169,807 through issuance and utilization of 48 scholarships. In the next
cycle, we expect moderate to extensive use by 20 of 36 investigators. The Proteomics Module, housed in a
centralized location conveniently accessed from all parts of campus, is directed by Professor Kevin Schey,
PhD, who also directs a subset of the MSRC sub-cores. Using resources and personnel supported in part by
this Core mechanism, the VVRC Proteomics Module will assist in (1) experimental design for proteomics,
metabolomics, or imaging mass spectrometry projects and (2) preparation of visual system tissues for mass
spectrometry analysis and provide (3) comprehensive proteomics service, (4) a range of small molecule and
metabolomics services, (5) access to imaging mass spectrometry (IMS) services, and (6) training to members
of the vision research community in LC-MS or IMS techniques. These services and resources will enhance the
scope of experimentation NEI-funded VVRC investigators conduct, expand the training of students and fellows
involved in vision science, and promote collaboration by providing sophisticated, high-resolution and high-
throughput proteomics and bioinformatic services to those who otherwise would not have such capabilities,
including early-career vision scientists and clinician-scientists competing for extramural funding for their
laboratories.

## Key facts

- **NIH application ID:** 10246442
- **Project number:** 5P30EY008126-34
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Kevin L Schey
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $59,660
- **Award type:** 5
- **Project period:** 1997-04-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10246442

## Citation

> US National Institutes of Health, RePORTER application 10246442, Proteomics Core (5P30EY008126-34). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10246442. Licensed CC0.

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