# Defining and targeting mechanisms of pancreas cancer pathogenesis

> **NIH NIH R50** · FRED HUTCHINSON CANCER RESEARCH CENTER · 2021 · $77,889

## Abstract

Project Summary
Dr. Martin Whittle is a senior scientist working in the laboratory of Dr. Sunil Hingorani at the Fred Hutchinson
Cancer Research Center. Dr. Whittle’s training has provided him a strong foundation in the fields of molecular
biology, cancer cell signaling, and tumor modeling in mice. This Research Specialist award will support Dr.
Whittle’s effort on research projects central to the overall Hingorani Laboratory research program including the
following three key projects: the complex pancreas cancer microenvironment and its contributions to disease
pathogenesis and drug resistance; the immune reaction in PDA and development of effective
immunotherapies; and the molecular underpinnings of the metastatic switch in pancreas cancer. Aside from
performing vital experiments for each of these projects, Dr. Whittle further supports the Hingorani lab by
training new technicians and postdoctoral fellows in fundamental and advanced laboratory techniques that are
critical to the Hingorani research program, including genetic engineering, mouse model development and
characterization, animal husbandry, surgical procedures and necropsies, primary tissue culture, histochemistry
and immunohistology, genotyping PCR, qRT-PCR, western blotting, FACS, fluorescence microscopy, gene
array, molecular cloning, ELISA, mass spectrometry and others.

## Key facts

- **NIH application ID:** 10246463
- **Project number:** 5R50CA211425-05
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **Principal Investigator:** Martin Whittle
- **Activity code:** R50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $77,889
- **Award type:** 5
- **Project period:** 2017-09-19 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10246463

## Citation

> US National Institutes of Health, RePORTER application 10246463, Defining and targeting mechanisms of pancreas cancer pathogenesis (5R50CA211425-05). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10246463. Licensed CC0.

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