# Project 1

> **NIH NIH P20** · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2021 · $89,952

## Abstract

Abstract:
Currently there are no biomarkers to separate good from poor prognosis luminal B breast cancers. Poor
prognosis luminal B breast cancers are only identified after a woman fails to respond to neo-adjuvant therapy
and options for cure are limited. While recent efforts have focused on developing targeted agents for triple-
negative breast cancer, luminal B breast cancer has been understudied, particularly in Latina/Hispanic women.
Here,
we aim to investigate the biology of aggressive luminal B breast cancers in Latina/Hispanic women with
the overall goal of improving early detection and survival. Overexpression of the oncogenic transcription factor
c-MYC (MYC) promotes malignant transformation and predicts poor prognosis in women with luminal B breast
cancers. Recent studies show that, relative to Northern European Whites, Black women with luminal B breast
cancers have a high-frequency of MYC-overexpression[5]. Preliminary studies provide evidence that MYC is
also frequently overexpressed in Latinas. UC Riverside (UCR) P20 PI Dr. Ernest Martinez studies the
mechanistic role of MYC-acetylation in promoting glycolysis and cellular transformation. City of Hope (CoH)
investigator, Dustin Schones studies the role of glycolysis in driving abnormal chromatin acetylation and
aberrant transcription. In this pilot, we aim to leverage these discoveries to target MYC-acetylation for drug
development. In this Early Drug Pipeline Pilot study, we aim to test the hypothesis that MYC-driven
mitochondrial Acetyl-CoA overproduction in luminal B breast cancer 1) promotes abnormal chromatin opening
and enhances the oncogenic functions of MYC and 2) predicts poor survival. Findings will be translated to test
whether MYC-acetylation is a promising target for early detection and/or treatment of luminal B breast cancer
in Latinas. Aim 1 will test whether chromatin acetylation and/or acetylation of the MYC oncogenic transcription
factor predicts poor prognosis in Southern California Latinas with luminal B breast cancer. Aim 2 will target the
acetylation/metabolic functions of MYC in high-throughput screening and mouse PDX models derived from
MYC+ luminal B breast cancers from Los Angeles Latina women.

## Key facts

- **NIH application ID:** 10246846
- **Project number:** 5P20CA242619-03
- **Recipient organization:** BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- **Principal Investigator:** Dustin Edward Schones
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $89,952
- **Award type:** 5
- **Project period:** 2019-09-02 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10246846

## Citation

> US National Institutes of Health, RePORTER application 10246846, Project 1 (5P20CA242619-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10246846. Licensed CC0.

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