# Assay Core

> **NIH NIH P01** · UNIVERSITY OF CHICAGO · 2021 · $234,637

## Abstract

Summary 
Core A measures serum, serum ultrafiltrate, plasma and urine stone risk chemistries and calculates urine 
supersaturations for patients studied in Projects 1 and 2. These measurements are used for fulfillment of aims 
within all four central program project objectives. Upper limit of metastability (ULM) for calcium oxalate and 
calcium phosphate in urine will be measured for Project 1. Core A will also measure plasma renin for Project 1. 
Blood and urine samples are processed and shipped for assay of lithium done in Core B, measurement of 
inflammatory markers in Core D and measurement of intact parathyroid hormone (PTH), aldosterone, 25(OH)- 
vitamin D and 1,25-dihydroxyvitamin D (performed by LabCorp). Urine exosomes will be prepared for 
molecular expression studies of renal ion transporter proteins. Aliquots of all blood and urine specimens are 
stored at -80°C for future use. All laboratory data from Core A for all projects are consolidated into a single 
database with daily backup for security and ease of analysis. Ultimately, data from the other projects and cores 
(e.g. histology, biopsy, stone analysis etc.) will be consolidated into our database so that it can be analyzed 
along with serum and urine data.

## Key facts

- **NIH application ID:** 10246874
- **Project number:** 5P01DK056788-20
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** KRISTIN J BERGSLAND
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $234,637
- **Award type:** 5
- **Project period:** 2000-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10246874

## Citation

> US National Institutes of Health, RePORTER application 10246874, Assay Core (5P01DK056788-20). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10246874. Licensed CC0.

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