# Unraveling the Complexities of Risk and Mechanism in Cancer

> **NIH NIH R35** · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2021 · $934,096

## Abstract

Project Summary/Abstract:
 Cancer is a complex disease in which multiple genetic, genomic, epigenetic, environmental, and other
factors combine to influence one’s risk—and ultimately to mediate cancer development and progression. While
cancer researchers recognize this complexity, most analytical methods in use have been built around relatively
simple approximations that fail to capture the multifactorial nature of cancer. During the past few years, my
colleagues and I have worked to develop new methodological approaches to analyze the nature of complex
diseases such as cancer. At the heart of these methods is the postulate that what defines each phenotype is a
characteristic network, that differences in networks between phenotypes can provide insight into biological
mechanisms, and that the structure and properties of these networks can shed light on the factors that drive
disease risk, development, and progression. While many methods have been developed to model networks,
we believe that what distinguishes our methods is that they use our understanding of biological processes,
such as transcription, to seed the model in a principled way and that, by design, their goal is translational,
bridging the gap between mathematics and medicine to support our understanding of cancer. This R35 project
would allow me to build on my successes, expanding my work in systems biology approaches by integrating
multi-omic and multi-factorial cancer data into our models with an emphasis on providing insight into both the
underlying biology of cancer and new ways to treat and manage the disease.

## Key facts

- **NIH application ID:** 10246935
- **Project number:** 5R35CA220523-04
- **Recipient organization:** HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH
- **Principal Investigator:** John Quackenbush
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $934,096
- **Award type:** 5
- **Project period:** 2018-09-01 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10246935

## Citation

> US National Institutes of Health, RePORTER application 10246935, Unraveling the Complexities of Risk and Mechanism in Cancer (5R35CA220523-04). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10246935. Licensed CC0.

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