# Molecular mechanisms of ARF family GTPases

> **NIH NIH R35** · EMORY UNIVERSITY · 2021 · $490,065

## Abstract

Project Summary/Abstract
 Members of the ARF family of regulatory GTPases function as nodes in cell signaling to
coordinate essential cell processes; including membrane traffic, energy metabolism,
ciliogenesis, and the cytoskeleton. I have studied first ARF and later ARF-like (ARL) proteins for
over 30 years, using a combination of biochemical, cell and molecular biological, and
phylogenetic approaches and propose to continue these studies with a focus on their actions at
specific sites; including mitochondria, cytosol, cilia, and centrosomes. We will both study
mechanisms by which one GTPase acts in multiple sites in the same cells, to explore the
potential for cross-talk or higher level ordering of cell signaling, but also explore novel, single
actions for atypical GTPases as a means of determining shared or unique mechanisms within
the family. A better understanding of these systems will reveal novel insights into fundamental
aspects of cell biology as well as providing potential targets for intervention to alter the course of
human diseases; including but not limited to cancer, heart disease, neurodegeneration,
ciliopathies, retinal degeneration, and deafness.

## Key facts

- **NIH application ID:** 10247516
- **Project number:** 5R35GM122568-05
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Richard A Kahn
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $490,065
- **Award type:** 5
- **Project period:** 2017-09-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10247516

## Citation

> US National Institutes of Health, RePORTER application 10247516, Molecular mechanisms of ARF family GTPases (5R35GM122568-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10247516. Licensed CC0.

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