# Admin Core

> **NIH NIH U54** · NORTHWESTERN UNIVERSITY · 2021 · $73,017

## Abstract

PROJECT SUMMARY – ADMINISTRATIVE CORE 
We propose to create a multi-institutional CHANNELOPATHY-ASSOCIATED EPILEPSY RESEARCH 
CENTER that will combine high-throughput technologies for functional evaluation of epilepsy-associated ion 
channel gene variants with high-content human neuron and animal model systems. The Center will be 
comprised of an integrated set of 3 research projects and 2 scientific cores involving a synergistic mixture of 
academic and industry scientists. Specifically, our Center will involve the efforts of more than 20 scientists and 
physicians affiliated with 5 academic medical centers, 3 free standing research hospitals, and 2 industry 
partners working together to investigate the functional consequences of variants in voltage-gated ion channel 
genes that are the most frequently discovered cause of genetic epilepsy. The research will be interdisciplinary 
and multi-faceted involving novel technologies and unique resources. The assembled investigative team is 
collegial and collaborative and this will contribute to the overall success. 
The Administrative Core will be responsible for managing and coordinating all major activities of the Center in 
the most efficient and cost effective manner to accomplish our major goals and to achieve milestones. This 
administrative oversight will involve coordination of all research components of the Center, communication 
among all participants, and engagement of other stakeholders from various professional and non-professional 
community partners. The aims of the Administrative core are: 1) to manage and coordinate all administrative 
and collaborative activities of the Center; 2) to facilitate communication across participating institutions and 
community partners; and 3) to enable public awareness of Center activities and ensure resource sharing.

## Key facts

- **NIH application ID:** 10247552
- **Project number:** 5U54NS108874-04
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Alfred L. George
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $73,017
- **Award type:** 5
- **Project period:** 2018-09-30 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10247552

## Citation

> US National Institutes of Health, RePORTER application 10247552, Admin Core (5U54NS108874-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10247552. Licensed CC0.

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