# Clinical Core

> **NIH NIH P20** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2021 · $668,218

## Abstract

PROJECT SUMMARY/ABSTRACT
 The Clinical Core (CC) will enroll participants in a carefully considered cohort to with a primary goal in the
P20 phase of demonstrating the feasibility of collecting the proposed dataset from a cohort with substantial
representation of groups disparately affected by Alzheimer’s disease and related dementias (ADRD) in the
Deep South, and establishing the capacity to perform all critical Clinical Core functions. Projected enrollment
will include 50 new participants annually for 3 years. The cohort will include cognitively unimpaired (~50%),
MCI (~30%) and mild dementia (~20%). Black or African American (B/AA) participants will be over-
represented in the cohort, working closely with the Community Outreach, Diversity, and Inclusion Core. The
Core will collect the uniform dataset, several other cognitive and functional measures, and evaluation of social
determinants of health and vascular risks. Fluid biomarkers including blood and urine will be collected from all
participants, with CSF optional but encouraged. Genotyping from blood samples will be conducted with
colleagues in the UAB-HudsonAlpha Center for Genomic Medicine and shared via NIAGADS. CSF, blood
products, and urine will be banked for local access and shared via NCRAD. A subset of participants will
receive neuroimaging, which includes structural and functional MRI, [11C]PiB amyloid PET, and [18F]flortaucipir
Tau PET. A multidisciplinary Clinical Consensus Conference will determine diagnostic clinical classifications.
A separate Biomarker Consensus Conference will classify individuals to A/T/N categories while blinded to the
clinical data and classification. Data from sequential clinical assessments will be collected and submitted to
NACC per UDS protocols. Well-characterized participants will be referred to clinical investigators approved via
the ADRC’s Data Sharing and Protocol Review process. Pre-mortem autopsy coordination and consent, as
well as longitudinal assessment data will be collected on behalf of the brain donation program.

## Key facts

- **NIH application ID:** 10247594
- **Project number:** 5P20AG068024-02
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** DAVID S GELDMACHER
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $668,218
- **Award type:** 5
- **Project period:** 2020-09-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10247594

## Citation

> US National Institutes of Health, RePORTER application 10247594, Clinical Core (5P20AG068024-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10247594. Licensed CC0.

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