# Biospecimen and Pathology Core

> **NIH NIH P50** · BAYLOR COLLEGE OF MEDICINE · 2021 · $278,526

## Abstract

PROJECT SUMMARY/ ABSTRACT
The purpose of this resource is to provide tissue, cells and pathology services to all 4 research projects and
career enhancement or research development awardees covered by this application. To achieve this goals
the Lymphoma SPORE is combines pathology resources of the Dan L Duncan Comprehensive Cancer
Center (DLDCC) at Baylor College of Medicine (BCM) and its affiliated institutions with those of Houston
Methodist Hospital to ensure adequate numbers and timely delivery of tissue/blood samples for the
projected needs of project investigators. It therefore co-ordinates acquisition of tissue for banking from
lymphoma and CLL patients at affiliated hospitals in the Texas Medical Center, by relying on established
tissue collection and distribution systems. The capacity to obtain samples from multiple affiliated hospitals
will greatly increase the number of specimens we are able to analyze, store and distribute. The core also
provides pathology services including routine tissue preparation, immunohistochemical staining, laser
capture microdissection, preparation of tissue microarrays, flow cytometry, detection of minimal residual
disease and in situ hybridization for viral RNAs. These tasks are essential to the successful completion of
planned experiments in each project and will be performed by expert pathologists and histotechnologists
with substantial experience in providing core services to SPORE investigators. It also co-ordinates supply of
tissue to the Patient-Derived Xenograft and Advanced In Vivo Models Core of the DLDCC. This core also
accesses a cancer genetics laboratory for specialized molecular studies including FISH and sequencing
and bioinformatics support to support tissue-banking software needs for the lymphoma SPORE.
Bioinformatics support comes from the DLDCC Bioinformatics Resource that utilizes Acquire, a secure web-
based modular application that serves as the unifying hub for all DLDCC-based biorepositories, including
the BCM Breast and Lymphoma SPOREs. In the last funding period the Resource Allocation Committee
approved 30 requests from SPORE and external investigators for tissue or blood samples.

## Key facts

- **NIH application ID:** 10247737
- **Project number:** 5P50CA126752-15
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Andrea Nicole Marcogliese
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $278,526
- **Award type:** 5
- **Project period:** 2007-04-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10247737

## Citation

> US National Institutes of Health, RePORTER application 10247737, Biospecimen and Pathology Core (5P50CA126752-15). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10247737. Licensed CC0.

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