# Cellular and Synaptic Reorganization after Exercise Training

> **NIH NIH R01** · UT SOUTHWESTERN MEDICAL CENTER · 2021 · $405,000

## Abstract

The incidence of obesity and diabetes continues to rise. Alarmingly this is a trend that is not limited to
the United States; rather obesity and its co-morbidities such as type II diabetes mellitus are on the rise and
pose a serious threat to public health around the world. Thus, identifying effective strategies for body weight
and blood glucose control is a priority. Exercise provides multiple metabolic benefits, including improved
insulin sensitivity and body composition. Within the brain, the melanocortin system is an interface between
signals of metabolic state and neural pathways governing energy balance and glucose metabolism. In the
current proposal, we will identify cellular mechanisms through which exercise alters the synaptic and cellular
properties of hypothalamic melanocortin neurons. We will also determine a role for these acute/chronic cellular
mechanisms to regulate metabolism.

## Key facts

- **NIH application ID:** 10247767
- **Project number:** 5R01DK119169-04
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** KEVIN W WILLIAMS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $405,000
- **Award type:** 5
- **Project period:** 2018-09-20 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10247767

## Citation

> US National Institutes of Health, RePORTER application 10247767, Cellular and Synaptic Reorganization after Exercise Training (5R01DK119169-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10247767. Licensed CC0.

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