# Non-invasive efficient brain delivery of Prussian Blue for treatment of Alzheimer disease

> **NIH NIH R44** · WEINBERG MEDICAL PHYSICS, LLC · 2021 · $764,512

## Abstract

Abstract
Direct brain injection of radical-scavenging dyes (e.g. Prussian blue) prevents and cures
Alzheimer’s disease in animal models. In human tests of orally administered blue dyes,
however, reaching therapeutic concentration levels in the brain has not been achievable.
Our published rodent experiments have shown that helical magnetic fields can drill
magnetic nanorods from the nose into the brain with very high efficiency. Rodent studies
have shown no toxicity after 30-days of particle implantation. In the first phase of this fast-
track project, we will validate that our magnetic drilling methods can deliver therapeutic
levels of blue dye in the brain non-invasively. In the second phase we will verify that this
delivery method improves cognition in a rodent model of Alzheimer disease (AD).
Accomplishment of this goal will pave the way to human studies, aided by already-
committed investors in the project and by experienced academic partners with whom we
have worked for over a decade.

## Key facts

- **NIH application ID:** 10247835
- **Project number:** 5R44AG066386-03
- **Recipient organization:** WEINBERG MEDICAL PHYSICS, LLC
- **Principal Investigator:** Irving Weinberg
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $764,512
- **Award type:** 5
- **Project period:** 2019-09-15 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10247835

## Citation

> US National Institutes of Health, RePORTER application 10247835, Non-invasive efficient brain delivery of Prussian Blue for treatment of Alzheimer disease (5R44AG066386-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10247835. Licensed CC0.

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