# Biostatistics and Bioinformatics Core

> **NIH NIH P50** · DUKE UNIVERSITY · 2021 · $141,830

## Abstract

ABSTRACT – Biostatistics and Bioinformatics Core (Core 1)
The Biostatistics and Bioinformatics Core will serve as an essential central resource to support the common
quantitative needs of the three translational projects (Projects 1-3) as well as research developed within the
Developmental Research (DRP) and Career Enhancement Programs (CEP). Building on decades of
collaborative experience with Duke Brain SPORE investigators, the Core will use their expertise to help
investigators frame study objectives and to ensure rigorous research design, conduct, analysis, and inference.
The Core will provide biostatistical leadership and expertise in the study design, conduct, sample size
calculations, randomization, monitoring, analysis, and reporting of clinical studies in brain cancer by
collaborating at all project stages, from study design to interpretation and publication of results (Aim 1). In
addition, Core 1 will contribute bioinformatics expertise to the conduct, analysis, and reporting of correlative
studies associated with clinical trials (Aim 2). Expertise is provided for the analysis of data from polychromatic
flow cytometry, intracellular staining, and TCR sequencing data. Finally, the Core will facilitate integration of
clinical, laboratory, and correlative data generated by Projects and Cores, and to promote data integrity (Aim
3). In partnership with the Administrative Core, an exemplary research culture will be promoted where the best
data management practices will be used throughout the SPORE in order to ensure data integrity, provenance
and security, and reproducibility of study findings. Though oversight of quality control and quality assurance is
provided by the Administrative Core, each individual Core has a role in maintaining data quality and providing
an infrastructure within which reliable and valid data is gathered. This Core will provide infrastructure for the
Clinical Trial Operations Core (Core 2) and the Biorepository, Pathology and Immune Monitoring Core (Core 3)
to collect quality data, and will be responsible for the integration of data from various sources for statistical
analyses. Taken together, the Biostatistics and Bioinformatics Core's contributions to investigating the safety,
activity and mechanisms of novel immunotherapeutic approaches to the treatment of patients with glioma are
critical to the achieving our shared goals of improving treatment of GBM.

## Key facts

- **NIH application ID:** 10248312
- **Project number:** 5P50CA190991-08
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** JAMES E HERNDON
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $141,830
- **Award type:** 5
- **Project period:** 2014-09-24 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10248312

## Citation

> US National Institutes of Health, RePORTER application 10248312, Biostatistics and Bioinformatics Core (5P50CA190991-08). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10248312. Licensed CC0.

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