# Indiana Core Center for Clinical Research in Musculoskeletal Health

> **NIH NIH P30** · INDIANA UNIVERSITY INDIANAPOLIS · 2021 · $776,745

## Abstract

Musculoskeletal disorders are common and result in significant disability and health care costs.
Advancements in the diagnosis and treatment of musculoskeletal disorders requires a robust clinical research
infrastructure and improved classification of the various disorders. The latter is critical to precision or
personalized medicine approaches as many musculoskeletal disorders have common clinical presentations of
pain and impaired physical function despite diverse pathophysiology. Furthermore, research to date often
focuses on bone or muscle and not how they interact. The overarching theme of the Indiana Core Center for
Clinical Research (ICCCR) is to enhance clinical research in musculoskeletal disorders and to understand the
muscle-bone connection by better defining, or phenotyping, this broad class of disorders in order to advance
clinical research. The ICCCR will leverage campus resources of our CTSA that includes Indiana and Purdue
Universities, our statewide healthcare system IU Health, the Regenstrief Institute's statewide electronic health
record system, and the Precision Health Initiative to enhance clinical research. The ICCCR will work with
Thematic Teams of multi-disciplinary investigators to create innovative ways to think about musculoskeletal
disorder phenotypes. The ICCCR will support individuals to connect investigators and Thematic Teams to the
methodologic and resource cores thereby facilitating access to and help in conducting research that 1) utilizes
our vast network of electronic health records, omics, and bioinformatics group to create computable, genetic
and molecular phenotypes, 2) develops standardized physical function and imaging modalities to develop
functional and morphologic phenotypes, and 3) expands the Indiana Biobank's musculoskeletal tissue and
blood resources. The ICCCR will work with community and industry partners to facilitate recruitment and
technology transfer and provide pilot funding to support new research. These new and innovative initiatives
under the ICCCR will link our musculoskeletal researchers of Indiana Center for Musculoskeletal Research to
state of the art resources to identify novel targets for diagnosis and treatment of musculoskeletal disorders.
We will challenge the traditional approach of bench to bedside research to instead focus on patient phenotype
to bench and back research. This will improve the definition and diagnosis of the many musculoskeletal
disorders to diseases that have common pathogenesis and clinical presentations, facilitating personalized
medicine by focusing the right treatment for each patient.

## Key facts

- **NIH application ID:** 10248402
- **Project number:** 5P30AR072581-05
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Sharon M Moe
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $776,745
- **Award type:** 5
- **Project period:** 2017-09-19 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10248402

## Citation

> US National Institutes of Health, RePORTER application 10248402, Indiana Core Center for Clinical Research in Musculoskeletal Health (5P30AR072581-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10248402. Licensed CC0.

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