# Administrative Core

> **NIH NIH P30** · INDIANA UNIVERSITY INDIANAPOLIS · 2021 · $160,002

## Abstract

Musculoskeletal disorders are common and result in significant disability and health care costs. 
Advancements in the diagnosis and treatment of musculoskeletal disorders requires a robust clinical research 
infrastructure and improved classification of the various disorders. The latter is critical to precision or 
personalized medicine approaches as many musculoskeletal disorders have common clinical presentations of 
pain and impaired physical function despite diverse pathophysiology. Furthermore, research to date often 
focuses on bone or muscle and not how they interact. The overarching theme of the Indiana Core Center for 
Clinical Research (ICCCR) is to enhance clinical research in musculoskeletal disorders and to understand the 
muscle-bone connection by better defining, or phenotyping, this broad class of disorders in order to advance 
clinical research. The ICCCR will leverage campus resources of our CTSA that includes Indiana and Purdue 
Universities, our statewide healthcare system IU Health, the Regenstrief Institute's statewide electronic health 
record system, and the Precision Health Initiative to enhance clinical research. The ICCCR will work with 
Thematic Teams of multi-disciplinary investigators to create innovative ways to think about musculoskeletal 
disorder phenotypes. The ICCCR will support individuals to connect investigators and Thematic Teams to the 
methodologic and resource cores thereby facilitating access to and help in conducting research that 1) utilizes 
our vast network of electronic health records, omics, and bioinformatics group to create computable, genetic 
and molecular phenotypes, 2) develops standardized physical function and imaging modalities to develop 
functional and morphologic phenotypes, and 3) expands the Indiana Biobank's musculoskeletal tissue and 
blood resources. In the Administrative Core, the leadership of will work to organize and facilitate project 
development of the Thematic Teams, evaluate the effectiveness of the Methodologic and Resource 
Core, enhance internal communication to ICCCR users and external outreach to the community and 
industry partners, and support pilot funding for new research. These new and innovative initiatives under 
the ICCCR will link our musculoskeletal researchers of Indiana Center for Musculoskeletal Research to state of 
the art resources to identify novel targets for diagnosis and treatment of musculoskeletal disorders. We will 
challenge the traditional approach of bench to bedside research to instead focus on patient phenotype to 
bench and back research. This will improve the definition and diagnosis of the many musculoskeletal 
disorders to diseases that have common pathogenesis and clinical presentations, facilitating personalized 
medicine by focusing the right treatment for each patient.

## Key facts

- **NIH application ID:** 10248403
- **Project number:** 5P30AR072581-05
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Sharon M Moe
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $160,002
- **Award type:** 5
- **Project period:** 2017-09-19 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10248403

## Citation

> US National Institutes of Health, RePORTER application 10248403, Administrative Core (5P30AR072581-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10248403. Licensed CC0.

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