# MEG evaluation of motor and cognitive control impairments underlying driving performance in ASD

> **NIH NIH R21** · CHILDREN'S HOSP OF PHILADELPHIA · 2021 · $197,506

## Abstract

PROJECT SUMMARY
Children, adolescents and adults with autism spectrum disorder (ASD)—a highly variable disorder—often have
difficulty with complex real-world tasks, impacting day to day life. It is unclear the extent to which these difficulties
stem from fundamental “low-level” neural compromise to the motor system compared to “higher level” cognitive
control systems that may mediate motor performance through processes of executive function. There are neural
signatures of both motor cortex function and executive function that can be determined from
magnetoencephalographic (MEG) recording during movements: beta-band oscillatory activity (15-30Hz) of the
motor system and theta-band (4-8Hz) activity of the anterior frontal lobe (neural substrates of executive function)
– frontal medial theta, FMT. Recent studies have demonstrated diminution and inter-individual variability in
adolescents with ASD of a component termed post-movement beta rebound (PMBR), which occurs shortly
following simple movement. However, these studies in common with the majority of the literature interrogate the
motor system via an experimentally-convenient, but poorly generalizable “button press” response, of little
relevance to real-life behavior. One real-life behavior of significant relevance to adolescent quality of life is
automobile driving. The challenges faced by adolescents with ASD in acquiring adequate driving skills (e.g.
speed regulation and lane maintenance) pose a severe limitation to their transition from adolescence to
independent adulthood. Whether these “motor” impairments stem from “low-level” motor cortex or “high-level”
cognitive control cannot, however, be readily assessed using simple visually-cued button-press tasks. We
capitalize on recently-developed MEG-compatible driving simulator technology, including both realistic software
and fiber-optic hardware to assess both low-level and high-level functional signatures in adolescents with ASD
(N=20, 15-17.99yrs) and age/sex-matched typically developing (TD) controls. We adopt a graduated
experimental design in which task-demands and context are manipulated to increase the ecological validity of
the paradigms – from simple button-presses cued by “driving-relevant” traffic light signals, through utilization of
simulator hardware (pedals/steering wheel) to assess realistic “moving” driving simulation. In each case,
responses will be obtained using identical cues (“stop” at red traffic light, “turn” on green arrow, etc.) with only
the context of the situation varying. We anticipate decreased PMBR in ASD. In TD adolescents we anticipate
the emergence of elevated FMT with increasing demand for cognitive control (e.g. during target tracking or
“controlled” braking/steering), which we hypothesize to be diminished in ASD. We anticipate that individual
differences in PMBR, FMT and phase-amplitude coupling (between FMT and motor gamma-band (PAC)) in
individuals with ASD will predict driving performance. This R21 will ...

## Key facts

- **NIH application ID:** 10248495
- **Project number:** 5R21NS118410-02
- **Recipient organization:** CHILDREN'S HOSP OF PHILADELPHIA
- **Principal Investigator:** William Charles Gaetz
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $197,506
- **Award type:** 5
- **Project period:** 2020-09-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10248495

## Citation

> US National Institutes of Health, RePORTER application 10248495, MEG evaluation of motor and cognitive control impairments underlying driving performance in ASD (5R21NS118410-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10248495. Licensed CC0.

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