# iPSC-CM Modeling to Define Sodium-Calcium Dysfunction in Heart Failure

> **NIH NIH P01** · STANFORD UNIVERSITY · 2021 · $513,960

## Abstract

Project Summary
Heart failure (HF) continues to have a major clinical and economic burden with stagnation in new therapies
over the past two decades. A significant barrier to improved therapies is the incomplete understanding of the
role of Na+/Ca2+ dysregulation in HF and its contribution to electrical and mechanical dysfunction. Project 1 of
this Program Project Grant (PPG) aims to elucidate the role of Na+/Ca2+ dysregulation in electro-mechanical
dysfunction associated with (HF) using human induced pluripotent stem cell-derived cardiomyocytes (iPSC-
CMs) based modeling. The Project will first phenotype DCM iPSC-CMs from individuals with heterogeneous
causative variants and genome edited controls. Then the role of molecular pathways that regulate Na+/Ca2+
homeostasis will be examined in each of the iPSC-CMs to define major pathways implicated in electro-
mechanical dysfunction and delineate genotype-specific mechanisms within DCM. Drug treatment cellular
responses and gene expression profiles will then be used to define genotype-specific drug responses and
novel drug targets. We are well positioned to achieve the project goals within five years. The ability to define
genotype-based mechanisms and drug treatments within HF is well aligned with NIH and NHLBI goals of
precision medicine models.

## Key facts

- **NIH application ID:** 10249147
- **Project number:** 5P01HL141084-03
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Joseph C. Wu
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $513,960
- **Award type:** 5
- **Project period:** 2019-09-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10249147

## Citation

> US National Institutes of Health, RePORTER application 10249147, iPSC-CM Modeling to Define Sodium-Calcium Dysfunction in Heart Failure (5P01HL141084-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10249147. Licensed CC0.

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