# Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (DMCC)

> **NIH NIH U24** · FRED HUTCHINSON CANCER RESEARCH CENTER · 2021 · $389,953

## Abstract

Project Summary
The key for the success of the Consortium on Translational Research in Early Detection of Liver
Cancer (Consortium) lies in good communication among scientists in multiple disciplines; efficient
evaluation and prioritization of promising biomarkers; and rigorous validation studies to
demonstrate their clinical utilities in improving the surveillance and early detection of liver cancer
and stratifying the risk of liver cancer in patients with cirrhosis. The overall aims of the proposed
Data Management and Coordinating Center (DMCC) are to (i) enhance communication and
collaboration among Consortium investigators; (ii) coordinate Consortium collaborative research
and provide statistical support; (iii) develop and maintain an integrated research database and
biorepository database for Consortium studies; and (iv) help the Consortium develop and
implement strategies for biomarker translational paths.
Under the direction of the Consortium Steering Committee, the DMCC will 1) perform network
coordination and promote collaborations among scientific investigators by providing support for
Consortium meetings, developing and maintaining Consortium secure websites and listservs, and
producing and maintaining all Consortium documents; 2) support Consortium collaborative
studies by working with Consortium investigators on study design, protocol development, data
forms, and study manuals; coordinating and monitoring studies; tracking specimen sharing,
blinding, and randomization; and performing QA/QC and study evaluation; 3) develop and
maintain a Consortium integrated information management system that provides online, end-to-
end data management solutions, including study communications, regulatory compliance, remote
patient registration, clinical data capture, biospecimen sample management, imaging data
repository, document management, and informatic tools; and 4) use the phased biomarker
development guidelines and PRoBE study design standards to help the Consortium develop a
roadmap and strategies and ensure rigor and efficiency of the Consortium collaborative phase-2
and phase-3 studies using existing and newly collected specimens from heterogeneous cohorts.

## Key facts

- **NIH application ID:** 10249162
- **Project number:** 5U24CA230144-04
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **Principal Investigator:** Ziding Feng
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $389,953
- **Award type:** 5
- **Project period:** 2018-09-17 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10249162

## Citation

> US National Institutes of Health, RePORTER application 10249162, Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (DMCC) (5U24CA230144-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10249162. Licensed CC0.

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