# Molecular Pathology and Genomics Core

> **NIH NIH P01** · DANA-FARBER CANCER INST · 2021 · $251,824

## Abstract

PROJECT SUMMARY
Core C provides access to specialized professional and technical pathology services and genomic services
that are essential to the success of the Program. It does so by carrying out 3 overarching aims that support all
three P01 Projects: 1) provide pathology expertise needed for classification of primary human PTCLs and PDX
and murine PTCL models; 2) perform standard and novel in situ tests for biomarkers relevant to understanding
PTCL pathophysiology and its response and resistance to novel therapies; and 3) perform targeted exome
sequencing of a large cohort of well-characterized human PTCLs. The Core delivers these services at two
performance sites, one in Boston led by Jon Aster, which will deliver services supporting Aims 1 and 2, and the
second in North Carolina led by Sandeep Dave, which will deliver services supporting Aims 1 and 3. Delivery
of Aim 1 services relies on the Core's co-leader, Dr. Jon Aster, who is a practicing academic
hematopathologist with >25 years of experience with human and murine hematopathology, and is
supplemented by additional expertise in Project 1 (John Chan) and access to the Hematologic Malignancies
Research Consortium, which includes >25 institutions and has accrued over 1800 cases of T cell lymphomas,
a majority with paired normal tissue. Aim 2 services will be provided in Boston include standard histology and
immunohistology services and innovative, multiparametric immunofluorescence staining platforms, the Perkin-
Elmer Vectra platform and CyCIF is an iterative imaging platform that allows for evaluation of >50 different
markers on single FFPE slides. Aim 3 services are delivered at the North Carolina performance site by
performing targeted exome sequencing on 410 genes that are frequently mutated in lymphoma, initially using
DNA prepared from a cohort of 1833 PTCLs and paired normal tissue controls.

## Key facts

- **NIH application ID:** 10249209
- **Project number:** 5P01CA233412-03
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** JON C. ASTER
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $251,824
- **Award type:** 5
- **Project period:** 2019-09-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10249209

## Citation

> US National Institutes of Health, RePORTER application 10249209, Molecular Pathology and Genomics Core (5P01CA233412-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10249209. Licensed CC0.

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