# Yale Cooperative Center of Excellence in Hematology

> **NIH NIH U54** · YALE UNIVERSITY · 2021 · $813,850

## Abstract

Abstract
The purpose of the Yale Cooperative Center of Excellence in Hematology (YCCEH) is to facilitate and
enhance research by investigators engaged in nonmalignant hematology-related research. Our unique
focus is the application of emerging technologies to the study of normal and perturbed hematopoiesis. This
includes understanding stem cell biology, hematopoiesis, including the processes of self renewal,
expansion and differentiation of hematopoietic stem cells, through intermediate progenitor and precursor
stages, to mature differentiated and functional blood cells of different lineages. Members of our Research
Base are actively engaged in a wide range of topics in the field of hematology, from the stem cell to the
bone marrow microenvironment, from understanding mechanisms of hematologic disease to development
of novel therapeutic strategies for inherited and acquired disorders, from transfusion of red blood cells and
platelets to study of related complications. In parallel, specific technologies utilized across the YCCEH
reflect this diversity, with techniques from many fields utilized including cell signaling, genomics,
proteomics, RNA biology, molecular biology, advanced imaging and microscopy, to better understand
hematologic processes. The resources and environment of the Yale University School of Medicine have
been and continue to be particularly well suited to the Center because of the interests and expertise of
many of its faculty in the areas of hematology, stem cell biology, genomic analyses and bioinformatics.
The availability of a large range of existing core facilities at Yale that directly interface with the YCCEH’s
cores, such as the Yale Stem Cell Center, the Yale Center for Genome Analysis, the Yale Center for
Clinical Investigation, the Yale Center for Medical Informatics, the Yale Center for High-Performance
Computation in Biomedicine, the Yale Systems Biology Institute and the newly established DeLuca Center
for Research in Hematology further synergize hematology research across the university. Together, these
resources support numerous critical core facilities relevant to hematology investigators. The YCCEH will
continue to serve our Research Base (both at Yale and external) by providing training and expertise
through the Emerging Technology Research Cores, while providing enhanced opportunities for education
and interactions through the Enrichment Core. The Emerging Technology Research Cores will not only
enhance research by providing access to cutting edge technologies, but also improve cost-effectiveness
of supported research. The long term goal of the YCCEH is to play a key role in the integrated program of
hematologic diseases-related research support provided by other NIDDK Cooperative Centers of
Excellence in Hematology by providing opportunities to promote increased collaboration within our
Research Base and with investigators at other institutions, supporting a broad and deep hematologic
diseases research base.

## Key facts

- **NIH application ID:** 10249339
- **Project number:** 5U54DK106857-07
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** PATRICK G GALLAGHER
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $813,850
- **Award type:** 5
- **Project period:** 2015-08-01 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10249339

## Citation

> US National Institutes of Health, RePORTER application 10249339, Yale Cooperative Center of Excellence in Hematology (5U54DK106857-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10249339. Licensed CC0.

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