# Animal Modeling Core

> **NIH NIH U54** · YALE UNIVERSITY · 2021 · $273,764

## Abstract

PROJECT SUMMARY/ 
The mission of the Animal Modeling Core (AMC) is to provide research groups within the YCCEH and the larger 
scientific community access to the latest technologies for hematologic studies in animal models. In vivo studies 
allow researchers to ask questions about the function of molecules, cell populations, and tissues within the 
relevant spatial and temporal contexts. The YCCEH will continue to provide scientists training and facilitate 
research in mouse models of hematologic diseases. Importantly, the AMC will continue to develop and propagate 
the most innovative humanized mouse models for the study of human hematopoiesis and diseases thereof with 
the goal to overcome major shortcomings of current models. The AMC consists of two cores, the Humanized 
Mouse Core (HMC) and the Murine Stem Cell Transplantation Core (mSCTC). The Animal Modeling Core will 
be directed by Dr Richard Flavell, Sterling Professor of Immunobiology and co-directed by Dr. Stephanie Halene, 
Associate Professor and Acting Section Chief of Hematology. The HMC will offer expertise, technical assistance, 
and mice for human-into-mouse xenotransplantation studies. The mSCTC will offer training and technical 
assistance in the study of hematopoiesis and benign hematologic questions in mice. The Humanized Mouse 
Core will facilitate human-into-mouse xenotransplantation studies into immunodeficient mice. As a unique feature 
the Yale HMC will offer hematology researchers access to novel humanized immunodeficient mice optimized to 
support human hematopoietic stem cells, trilineage hematopoiesis, mature myeloid cells, red cells and platelets 
in circulation, and a functional human immune system. The Murine Stem Cell Transplantation Core will provide 
technical expertise in the study of hematologic questions in mice. The mSCTC will offer training and expertise 
for the study of hematopoiesis and hematologic diseases in mice using hematopoietic cell transplantation and 
functional assays. The Animal Modeling Core will be an integral part of the YCCEH. It will provide Hematology 
researchers with access to state-of-the-art technologies for in vivo studies of hematopoiesis and hematologic 
diseases. It will provide teaching, expertise, and resources in an economical way. Its cores will support basic 
science as well as translational studies, key to understanding and cure of hematologic diseases.

## Key facts

- **NIH application ID:** 10249344
- **Project number:** 5U54DK106857-07
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Richard A Flavell
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $273,764
- **Award type:** 5
- **Project period:** 2015-08-01 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10249344

## Citation

> US National Institutes of Health, RePORTER application 10249344, Animal Modeling Core (5U54DK106857-07). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10249344. Licensed CC0.

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