# Core C: Clinical and Population Sciences Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $382,383

## Abstract

Clinically impactful research regarding HIV disease ultimately requires direct investigation of at-risk or
HIV-infected human populations. Such human subjects-based research broadly includes, for example,
“bench to bedside” translational research, observational database-derived research, prospective cohort
investigation, experimental work, and implementation science. Each of these research disciplines is
sophisticated, requiring substantial infrastructure to pursue at the highest level. Some of the
disciplines, such as translational research, require considerable coordination across several
methodologic and substantive domains. To support clinically impactful research, particularly that which
is translational, the overall objective of the UCSF-Gladstone CFAR Clinical and Population Sciences
Core is to integrate the human subjects research methodologic disciplines of epidemiology and
biostatistics with the basic and clinical substantive science of HIV infection to facilitate human subjects-
based HIV-related research. Accordingly, the specific aims are to:
Aim 1: Provide expertise in the clinical and population sciences related to HIV/AIDS research via
 consultation regarding conception of research questions, study design, sources of data, data
 management, biostatistical analysis, and interpretation of data;
Aim 2: Manage unique prospective observational cohorts of HIV-infected adults in both San Francisco
 (SCOPE and Options) and Africa (UARTO and ISS Clinic Cohorts) that provide researchers with
 a diverse array of data and biological specimens from subjects who are well-characterized in
 terms of epidemiologic, clinical, laboratory and behavioral parameters;
Aim 3: Offer a platform for the efficient conduct of newly proposed prospective human subjects studies;
Aim 4: Mentor early stage investigators in the conduct of research involving human subjects.
The rationale for a core mechanism to offer these services is to provide multiple researchers with a
cost-efficient centralized resource that is not otherwise available through traditional funding sources.
Evidence of the utility of the Core's approach in the current funding cycle includes distribution of over
24,000 biological specimen samples, support of 243 projects and 296 core users (including 124 early
stage investigators), and facilitation of 184 publications in the past 4 years. In this proposed renewal,
the central functions of the Core will be unchanged, with support of both domestic and international
research, but several new additions and emphases are planned based on the institutional strengths at
UCSF-Gladstone, the agendas of major NIH-sponsored HIV/AIDS programs, and the research
initiatives being launched by local CFAR investigators.

## Key facts

- **NIH application ID:** 10249376
- **Project number:** 5P30AI027763-30
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** JEFFREY N MARTIN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $382,383
- **Award type:** 5
- **Project period:** 1997-03-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10249376

## Citation

> US National Institutes of Health, RePORTER application 10249376, Core C: Clinical and Population Sciences Core (5P30AI027763-30). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10249376. Licensed CC0.

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