# NON-INVASIVE WRIST-WATCH DEVICE FOR REMOTE MONITORING OF HEART FAILURE PATIENTS

> **NIH NIH R43** · INCARDIA INC. · 2021 · $224,700

## Abstract

ABSTRACT
The objective of this study is to prove the feasibility of an innovative diagnostic device for the detection and
monitoring of worsening heart failure. Heart failure affects 6.5 million of Americans and cost the US over $30B
a year in healthcare services, medications and missed work. These costs are expected to double by 2030.
Heart failure is associated with high healthcare utilization due to frequent hospital re-admissions. Heart failure
is the most common diagnosis in all hospital admissions in patients over 65. The readmission rate is high – over
20% by 30 days, and 30% by 90 days post-discharge. There is a significant need for in-home non-invasive
methods to detect early stages of destabilization in heart failure. Hemodynamic congestion defined as
increasing filling pressures in the heart typically precedes other clinical symptoms. Detection and monitoring of
hemodynamic congestion offers the healthcare professionals an opportunity to intervene by adjusting the
medications and to prevent acute heart failure episodes and hospitalizations.
This pilot clinical research study is designed to demonstrate that the innovative CorWatch™ technology is
effective in detecting hemodynamic congestion in heart failure. CorWatch™ detects increases in central venous
and right atrial pressures which are concordant with increase in the left heart filling pressures. Adult heart failure
patients undergoing cardiac catheterization in a cardiac lab will be recruited for this study. The specific aims are
to further develop CorWatch™ devices for the clinical trial; and to demonstrate a good agreement between the
CorWatch™ technology and the cardiac pressures measured with the gold standard – Swan Ganz catheter. If
this research study shows the effectiveness of the proposed diagnostic approach, CorWatch™ device can
potentially be integrated into clinical practice of cardiologists and other physicians as an easy-to-use in-home
non-invasive device for monitoring of heart failure. CorWatch™ will offer early warnings of worsening heart
failure and aid healthcare professionals in prevention of patient’s destabilization that can lead to acute heart
failure episode and hospitalization. Therefore, CorWatch™ has a potential to reduce the healthcare costs and
to improve quality of life of heart failure patients.

## Key facts

- **NIH application ID:** 10249748
- **Project number:** 1R43HL156691-01A1
- **Recipient organization:** INCARDIA INC.
- **Principal Investigator:** Maria Merchant
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $224,700
- **Award type:** 1
- **Project period:** 2021-07-01 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10249748

## Citation

> US National Institutes of Health, RePORTER application 10249748, NON-INVASIVE WRIST-WATCH DEVICE FOR REMOTE MONITORING OF HEART FAILURE PATIENTS (1R43HL156691-01A1). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10249748. Licensed CC0.

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