# 2/1 Arrest Respiratory Failure due to Pneumonia (ARREST PNEUMONIA)

> **NIH NIH U24** · STANFORD UNIVERSITY · 2021 · $351,676

## Abstract

Core Summary/Abstract 
The Arrest Respiratory Failure due to Pneumonia (ARREST PNEUMONIA) Data Coordinating 
Center (DCC) will fulfill an essential need to ensure that the ARREST Pneumonia trial will 
achieve its mission to establish the efficacy of ancillary therapy directly targeting the lung injury 
that occurs with pneumonia. Critical to carrying out the trial’s success is DCC oversight of the 
implementation of the study design and randomization scheme, performing the interim and final 
data analysis, regular data and safety monitoring reports, the timely dissemination of findings, 
and data and resource sharing. To meet its goals, the DCC will employ open-­source secure 
web-­based tools such as REDCap for housing data across the 10 sites and allowing web-­based 
randomization;; appropriate statistical techniques, including methods for the analysis of time-­to-­
event data in the presence of competing risks;; and expertise in clinical trial design and data 
safety monitoring. The DCC includes a stellar team with extensive experience in innovative 
clinical trial designs, statistical modeling, managing large and complex data sets, and monitoring 
data quality. Importantly, the operation of the DCC will rely heavily on the philosophy that DCC 
members should be fully integrated into the trial’s research team as well as in the infrastructural 
support in order to optimally meet the trials data-­related and coordination needs. To that end, 
the DCC is composed of five support teams corresponding to key support functions of a 
biostatistics and data coordinating center. The DCC’s structure will ensure the success of the 
scientific goals for ARREST Pneumonia by designing and monitoring the trial, developing a 
database in REDCap, providing specific expertise on safety monitoring and quality control, 
implementing analyses, and providing principal interpretation for dissemination.

## Key facts

- **NIH application ID:** 10249960
- **Project number:** 5U24HL141727-03
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** MANISHA DESAI
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $351,676
- **Award type:** 5
- **Project period:** 2019-09-15 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10249960

## Citation

> US National Institutes of Health, RePORTER application 10249960, 2/1 Arrest Respiratory Failure due to Pneumonia (ARREST PNEUMONIA) (5U24HL141727-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10249960. Licensed CC0.

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