# Core D: Data Management, Biostatistics, and Bioinformatics

> **NIH NIH U19** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2021 · $693,599

## Abstract

Abstract – Data Management, Biostatistics, and Bioinformatics Core D
The Data Management, Biostatistics, and Bioinformatics Core will provide a local and cloud-based data
management system for the entire Program Project that will enable Project-specific analyses, as well as
integrated analyses utilizing data spanning the entire Project. The Core will serve as the centralized data hub
for the establishment of the prospective RESPOND cohort of African American (AA) men with prostate cancer
(PCa). This includes: (1) questionnaire data, including multi-level factors related to social stressors, linkages to
neighborhood socioeconomic indicators that will be collected through the recruitment Core B and primarily
used in Project 1; (2) germline genome-wide genotype data and exome-sequencing data generated as part of
Project 2; (3) somatic and expression data generated as part of Project 3; (4) immune cell profiles assessing
the tumor microenvironment in Project 4; (5) and pathology related assessments of banked tumor specimens
from Core C. The Core will also provide statistical and bioinformatics support and expertise. As a cohesive
unit, the Core will leverage familiarity with data resources and commonalities of analysis across Projects.
Finally, the Core will serve as the foundation for performing integrated analysis. This includes sophisticated
integrated statistical analyses and access of joint results across Projects. The Core’s activities will be primarily
performed within the University of Southern California’s Biostatistics Division and Translational Genomics
group – benefiting from shared computational resources, active collaborations, and recent methodological
developments in statistical approaches, integrated analysis and informatics. The Core is essential to the overall
success of the Program Project as it serves as an incubator to process and store data, advise and complete
Project-specific analyses, and perform and accelerate cross-Project integration and discoveries.

## Key facts

- **NIH application ID:** 10249999
- **Project number:** 5U19CA214253-04
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** David V Conti
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $693,599
- **Award type:** 5
- **Project period:** 2018-07-05 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10249999

## Citation

> US National Institutes of Health, RePORTER application 10249999, Core D: Data Management, Biostatistics, and Bioinformatics (5U19CA214253-04). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10249999. Licensed CC0.

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