# Administrative/Coordination Core

> **NIH NIH U54** · UNIVERSITY OF CALIFORNIA-IRVINE · 2021 · $205,741

## Abstract

The NexGen Alzheimer's Disease Models Center (NG-ADMC) will be administratively housed within the
University of California, Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND). This
Organized Research Unit at UCI administers the NIH funded ADRC, an Alzheimer's disease focused NIH
Program Project Grant, an NIA Training Grant, and multiple other grants, requiring coordination of multiple
investigators and multiple disciplines to achieve objectives that will transform the future. The
Administrative/Coordination Core (ACC) of the NexGen Alzheimer's Disease Models Center will provide
coordination of the entire Center and ensure fiscal accountability. Drs. LaFerla and Tenner have collaborated
on multiple projects at UCI with complementing expertise in animal models, neuroinflammation, and
therapeutic targetings. A Center Administrator with extensive administrative experience, as well as laboratory
technical and management experience, will oversee daily transactions, organize routinely scheduled meetings,
and contribute to fiscal planning and execution The Steering Committee will be convened at least every two
months to review data and discuss any modification in procedures, direction, or priorities to facilitate the
progress across the Center. The External Advisory Board will be convened every six months with the Steering
Committee to affirm or modify Center activities toward achieving milestones of the multiple units. Importantly, a
Project Manager who is knowledgeable about the various phenotype characterizations and experimental
design will oversee the day-to-day placement of mice, including the efficient use of aged animals among the
Center investigators. In addition, the Manager will maintain the catalog and inventory of the tissue repository,
provide access to reagents/tissues under the guidance of the Co-PIs, and coordinate animal transfers to The
Jackson Laboratory (JAX). The ACC will lead Center program evaluation activities, including annual reports of
each core, and ensure communication among the units to accelerate progress toward achieving milestones.
The ACC will communicate Center activities with the NIH Program Official and implement suggestions received
from the NIH and the EAB.

## Key facts

- **NIH application ID:** 10250341
- **Project number:** 5U54AG054349-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** FRANK M LAFERLA
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $205,741
- **Award type:** 5
- **Project period:** 2017-09-15 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10250341

## Citation

> US National Institutes of Health, RePORTER application 10250341, Administrative/Coordination Core (5U54AG054349-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10250341. Licensed CC0.

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