# Genomic Analysis and Statistical Core

> **NIH NIH P01** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2021 · $274,430

## Abstract

PROJECT SUMMARY
Core B will also ascertain and recruit patients, as in cycle 1, and establish the clinical and phenotypic
classifications which are pivotal for Projects 1, 2 and 3. Core B will also acquire and manage all of the biologic
resources for the Program. The goal is to recruit appropriate PH patients and members of families, to
characterize the phenotypes and obtain the specimens needed to conduct all studies of the program, with the
central overall objective to understand the pathogenic mechanisms that contribute to PAH to facilitate the
development of novel translational therapies. Ongoing patient and family recruitment, phenotyping and
sampling are vital to the overall program success. Comparisons of phenotypic variation with genotypic variation
and the Omics analyses proposed in this project require the largest cohort available, in order to provide the
best possible power in each individual subset. Further recruitment is also needed to strengthen the power for
discovery for genotype phenotype correlations such as in expression quantitate locus (eQTL) mapping
proposed in this application. Core B will ensure the generation of high quality analyses through the revision
and refinement of the informatics pipelines and the development of statistical methodologies that can be
applied to the proposed project. Recent advances in genomics have led to the generation of massive quantities
of a diverse range of molecular data. Statistical methods for analyzing the complex, high-dimensional data
continue to evolve and require knowledge of advanced statistical techniques. Core B personnel and facilities
will perform the following key functions: 1. Ascertainment; 2 Recruitment; 3 Phenotyping; 4 Database entry and
maintenance; 5 Specimen acquisition and storage 6 Specimen retrieval and distribution; and 7 Biostatistics
and bioinformatics.

## Key facts

- **NIH application ID:** 10250452
- **Project number:** 5P01HL108800-11
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** RIZWAN HAMID
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $274,430
- **Award type:** 5
- **Project period:** 2012-09-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10250452

## Citation

> US National Institutes of Health, RePORTER application 10250452, Genomic Analysis and Statistical Core (5P01HL108800-11). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10250452. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*