# A scalable system for high-throughput and longitudinal electrophysiology in rodent brain research

> **NIH NIH R44** · SPIKEGADGETS, LLC · 2021 · $644,241

## Abstract

Psychiatric disorders give rise to aberrant patterns of activity within the complex neural circuits
of our brains. Yet, the exact nature of these abnormal patterns is often unknown to developers
of new treatments. The goal of this project is to enable circuit-oriented research of
neuropsychiatric diseases using rodent disease models. The long-term objective is to catalyze
the discovery of new therapeutic targets for a variety of disorders and to provide a tool to study
animal-to-animal variability in neural coding. A new type of research tool will be developed and
commercialized that is specialized for high-throughput, detailed, and long-term neural
measurements in behaving mice. Phase I enabled the development of a data logging system
prototype that is lightweight enough for a freely-moving mouse to carry as well as flexible
electrode technology that is minimally invasive to brain tissue. Throughout this next Phase-- in
partnership with UT Austin--a miniaturized data logging system will be further developed to
optimize weight, size, cost, and capabilities. Various probe parameters will be tested in vivo to
create target-optimized recordings for multiple brain regions. Final, user-customization will be
enabled through a web-based system configuration interface. By enabling high-throughput and
long-term recordings, this tool provides a practical way to study the progression of circuit
dysfunction using large cohorts of animal disease models.

## Key facts

- **NIH application ID:** 10250511
- **Project number:** 5R44MH118137-04
- **Recipient organization:** SPIKEGADGETS, LLC
- **Principal Investigator:** Mattias Peter Karlsson
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $644,241
- **Award type:** 5
- **Project period:** 2018-08-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10250511

## Citation

> US National Institutes of Health, RePORTER application 10250511, A scalable system for high-throughput and longitudinal electrophysiology in rodent brain research (5R44MH118137-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10250511. Licensed CC0.

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