# Individual differences in nicotine dependence: A multi-modal neuroimaging approach

> **NIH NIH K02** · MCLEAN HOSPITAL · 2021 · $15,005

## Abstract

Abstract
This application is for a new K02 Independent Scientist Career Development Award that seeks five years of
protected time to solidify my newly established independent laboratory the Functional Integration of Addiction
Research Laboratory. My laboratory focuses on defining individual risk factors for addictive disorders and their
related neurobiological mechanisms and is supported by my funded R01 (DA039135; July 2015-2020). The 5
years of protected time afforded by this K02 will facilitate this project's objectives by allowing me to (1) acquire
new skills in high-density electroencephalography (EEG/ERP) in conjunction with advanced source localization
techniques, and thus enable investigation of the spatio-temporal dynamics of mechanisms underlying
addiction; (2) mentor junior scientists; and (3) extend my research portfolio through collaborations. My research
to date has employed functional magnetic resonance imaging (fMRI), which in many cases can answer similar
questions as EEG. However, EEG has greater temporal resolution (on the order of milliseconds) than fMRI
(seconds) allowing for superior analysis of the spatiotemporal dynamics of brain mechanisms. Such
relationships can provide important clues regarding processes that go awry in those with addictive disorders.
Specifically, the proposed EEG collaboration will fundamentally extend the research objectives of my funded
R01 by identifying the neurobiological aspect of cognitive control disrupted in those who have difficulty ignoring
smoking cues, which is related to relapse vulnerability. In addition, through other planned collaborations I will
expand my research of smoking cue reactivity and nicotine dependence to include research into other
addictions (i.e., cocaine and opiates) and other risk factors for addiction (co-morbid psychiatric disorders). In
the absence of key protected K02 support, I would need to cover the balance of my salary through teaching at
the undergraduate level and committee work, which would significantly detract from these activities that are
key to a newly independent scientist.

## Key facts

- **NIH application ID:** 10250520
- **Project number:** 5K02DA042987-05
- **Recipient organization:** MCLEAN HOSPITAL
- **Principal Investigator:** Amy C Janes
- **Activity code:** K02 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $15,005
- **Award type:** 5
- **Project period:** 2017-09-01 → 2021-10-11

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10250520

## Citation

> US National Institutes of Health, RePORTER application 10250520, Individual differences in nicotine dependence: A multi-modal neuroimaging approach (5K02DA042987-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10250520. Licensed CC0.

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