# Flexible Hybrid Cloud Infrastructure for Seamless Management of HuBMAP Resources

> **NIH NIH OT2** · CARNEGIE-MELLON UNIVERSITY · 2020 · $599,997

## Abstract

To provide for the Infrastructure Component (IC) of the HuBMAP HIVE, Pittsburgh Supercomputing Center
(PSC) and the University of Pittsburgh (Pitt) will create a flexible and scalable hybrid cloud infrastructure in close
coordination with the HIVE Collaboratory, the HuBMAP Consortium, and stakeholders world wide. This proposed
IC will seamlessly connect HuBMAP with storage and co-located compute resources for depositing, accessing,
querying, searching, analyzing, and visualizing both raw and processed HuBMAP data. Data and tools
incorporated into the IC will be findable, accessible, interoperable, reusable (FAIR), and put together in
reproducible, shareable workflows that can be run locally and on all major public clouds. The IC services will be
flexible and extensible to incorporate new data, tools, technologies, security needs, federated identity and user
roles via modular architecture of APIs and containers. These features enable tools to be both rapidly deployed
and modifiable, defined as distinct functions with defined inputs and outputs, enabling solidly constructed
repeatable pipelines. The IC will provide the open data platform for study of tissue organization and function
through 3D biomolecular tissue maps in the spatial framework of the human body envisioned by HuBMAP.
Our vision for the HuBMAP infrastructure is flexible, efficient delivery on HuBMAP’s goals, on sustainable
platforms, by engaged and experienced leadership. We see the infrastructure component in a key service role
to other HIVE components, TMCs, NIH program, and interacting with other atlas projects. Our design is based
upon existing substantial persistent infrastructure supported by many projects with a 30-year history. At PSC,
HuBMAP will be sustained for decades at reasonable cost and/or integrate with other programs. In addition to
leadership and grounded technology expertise, we are proposing full-time project management and imaging and
data science expertise within our team. These capabilities will allow the infrastructure component staff to engage
as “ever-present” participants in any aspects of the discussions of the integrated collaboratory conceived by the
HuBMAP program (e.g. HIVE, TMCs, NIH staff). The structure of the HIVE enables the infrastructure component
to focus on delivery and the engagement required for delivery.

## Key facts

- **NIH application ID:** 10250640
- **Project number:** 3OT2OD026675-01S5
- **Recipient organization:** CARNEGIE-MELLON UNIVERSITY
- **Principal Investigator:** Philip D. Blood
- **Activity code:** OT2 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $599,997
- **Award type:** 3
- **Project period:** 2018-09-21 → 2022-09-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10250640

## Citation

> US National Institutes of Health, RePORTER application 10250640, Flexible Hybrid Cloud Infrastructure for Seamless Management of HuBMAP Resources (3OT2OD026675-01S5). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10250640. Licensed CC0.

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