# Core 2: Animal Models

> **NIH NIH P01** · OHIO STATE UNIVERSITY · 2021 · $356,287

## Abstract

PROJECT SUMMARY – CORE 2
The overall goal of Core 2 (Animal Model Core) is to support the development and use of the animal models
utilized within this Program Project Grant (PPG). The guiding principles for the animal model core are efficient
planning and utilization of animals, standardization of processing and diagnoses, reliability of service and
consistent evaluation of animal models. The fundamental expertise provided within the core is laboratory animal
medicine and clinical and anatomic pathology. The Core is housed and coordinated in the Department of
Veterinary Biosciences. Dr. Stefan Niewiesk, proposed Core Director has been Director of the Animal Core
since 2004 and is an active collaborator with all of the principal investigators for the PPG. Dr. Niewiesk is a
certified in Veterinary Microbiology and in Laboratory Animal Medicine (European College). Dr. Krista La Perle
(Co-Investigator), who is certified by the American College of Veterinary Pathology will provide pathological
evaluations for the Core. The overall theme of the PPG is to analyze how infection with HTLV-1 induces
proliferation of CD4 T cells, how viral latency and proteins influence and maintain transformation and how the
tumor cells interact with their microenvironment. After acute infection, HTLV-1 persists in the organism,
eventually leading to oligoclonal transformation and outgrowth of CD4 T cells. After establishment and
reactivation of viral latency (Project 3: Ratner), tumorigenesis is driven by the viral protein Hbz (Project 1:
Green). These leukemic cells spread throughout the organism and cause osteolysis (Project 2: Weilbaecher).
All projects will use rabbit and mouse models for adult T cell leukemia, which have been established and/or
utilized by Core 2 using a molecular clone of HTLV-1.

## Key facts

- **NIH application ID:** 10251306
- **Project number:** 5P01CA100730-17
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** STEFAN NIEWIESK
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $356,287
- **Award type:** 5
- **Project period:** 2003-04-21 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10251306

## Citation

> US National Institutes of Health, RePORTER application 10251306, Core 2: Animal Models (5P01CA100730-17). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10251306. Licensed CC0.

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