PROJECT SUMMARY/ABSTRACT The University of Utah has been one of the most productive sites in the NICHD Maternal-Fetal Medicine Units (MFMU) Network over the past 25 years, contributing numerous concepts and protocols, large numbers of well-characterized study participants, high-quality research data, and multiple important secondary analyses resulting in national presentations and awards. The specific aim of this application is to allow continuation of ongoing MFMU Network protocols for up to four years beyond the end of the current funding cycle (31 March 2021). The Utah center has submitted 25 proposals to the Network Steering Committee, of which 15 have been advanced to full protocol status. The Utah center is consistently among the leading Network centers for screening, recruitment and data quality. Torri Metz MD has served as the Utah center PI since early 2019. In addition to has numerous Network administrative responsibilities, she has worked tirelessly to ensure that the University of Utah – Intermountain Healthcare collaboration continues to be mutually beneficial. Twenty-six Board-Certified/Board Eligible MFM Division faculty plus 6 MFM Fellows provide 24/7/365 coverage for the 5 participating Utah hospitals. The 5 participating hospitals represent ~18,000 deliveries per year (40% of the deliveries in the State of Utah). The population recruited into MFMU Network studies over the previous 25 years is representative of the population of the northern Utah urban corridor. Letters of support are provided from the NICU Directors at all hospitals and representative statistics are also provided. The University of Utah Developmental Assessment Center provides research follow-up for MFMU Network and Utah Neonatal Research Network protocols. Long-standing functional data systems exist in all 5 participating hospitals. Twenty-nine research personnel work on MFMU Network protocols in 5 hospitals and the offices of over 100 women’s health providers along the Utah urban corridor. These individuals are dedicated clinical researchers, with a low turn-over rate. The University of Utah is enthusiastically committed to continued participation in the NICHD MFMU Network, as confirmed by multiple letters of support. The proven and continuing ability of Drs. Metz, Esplin and Varner to enlist wide-spread participation by community obstetric providers and to attract/retain an excellent clinical research staff are major factors in the success of the Utah site and will continue through the completion of ongoing Network protocols, should the Utah center be selected for continued Network participation.