# A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF 4-HYDROXYTAMOXIFEN TOPICAL GEL IN WOMEN WITH MAMMOGRAPHICALLY DENSE BREASTS

> **NIH NIH N01** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2020 · $95,578

## Abstract

The goal of this solicitation is to develop, conduct and analyze a randomized three-arm breast cancer prevention study among women age 40-50 years of age or <40 years if Gail risk ≥1.66 (including BRCA1/2 mutation carriers) with mammographically dense breasts (BIRADS C or D, according to fifth edition classification) to assess whether daily application of 2 mL or 4 mL of afimoxifene (4-hydroxytamoxifen) gel lowers breast density.

## Key facts

- **NIH application ID:** 10252736
- **Project number:** 261201200034I-P00004-26100011-1
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** POWEL BROWN
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $95,578
- **Award type:** —
- **Project period:** 2016-09-19 → 2021-09-18

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10252736

## Citation

> US National Institutes of Health, RePORTER application 10252736, A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF 4-HYDROXYTAMOXIFEN TOPICAL GEL IN WOMEN WITH MAMMOGRAPHICALLY DENSE BREASTS (261201200034I-P00004-26100011-1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10252736. Licensed CC0.

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