# Resource Core

> **NIH NIH P20** · UNIVERSITY OF HAWAII AT MANOA · 2021 · $501,620

## Abstract

Abstract:
The overall objective of the Resource Core is to provide an easily accessible, modern, and local set of
expertise in cellular and animal metabolism and the epigenetics associated with diabetes to ultimately provide
a sustainable resource for the biomedical research community to assess cellular and animal metabolics along
with the genetic changes associated with a clinical diagnosis. The central hypothesis for this Resource Core
is that the core will provide an unprecedented set of expertise, education, and training by establishing the
infrastructure necessary to investigate the mechanisms, diagnosis, prevention, and/or treatment of diabetes in
a multi-faceted approach to improve health and address health disparities in minority populations in Hawaii.
The following aims will support the goals of the Resource Core to achieve the overall objective.
Specific Aim 1: Establish a cell and animal metabolic facility for the growing number of investigators
interested in studying diabetes.
We plan to enhance cellular metabolic instrumentation and install animal metabolic infrastructure to study
diabetes. We will provide services in, in-vitro to in-vivo metabolic studies including the design, development,
optimization, and delivery as requested, as we have extensive expertise in cellular metabolism and animal
models.
Specific Aim 2: Establish an epigenetics facility to evaluate heritable variations and transcriptional
changes in genes associated with diabetes.
We have extensive expertise in gene expression studies to develop and deliver a wide-array of epigenomic
services. We plan to enhance the epigenetics core by providing expertise and ground-breaking technology like
MeDIP-, ChIP-, gDNA-, Ampli-, and RNA- sequencing and bioinformatics data analysis. This technology will
be accessible to interested investigators.
Specific Aim 3: Provide education and instruction in the resources and capabilities of the Core.
Cores are critical to produce high quality data but also to the training and development of “quality”
investigators. The advantage of a core is the consistency and quality of the work performed. Specifically,
this core will include training and facilitation of use to assess cellular metabolism (Seahorse XFe96),
animal metabolism (GTT, ITT, hyperglycemic and hyperinsulinemic-euglycemic), and genetic variation
(Ion Personal Genome Machine®). We plan to integrate a fee for service/cost recovery/sharing plan to
ensure that the core is self-sustaining while integrating new technologies in the field.

## Key facts

- **NIH application ID:** 10252772
- **Project number:** 5P20GM113134-05
- **Recipient organization:** UNIVERSITY OF HAWAII AT MANOA
- **Principal Investigator:** OLIVIER LE SAUX
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $501,620
- **Award type:** 5
- **Project period:** 2017-08-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10252772

## Citation

> US National Institutes of Health, RePORTER application 10252772, Resource Core (5P20GM113134-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10252772. Licensed CC0.

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