Project Summary. The Biostatistics & Bioinformatics Resource Core (BBC) supports vision scientists at Washington University by providing assistance with experimental design and analysis of quantitative data. In response to the expressed needs of the user group, the core has been strengthened significantly by incorporation of enhanced Bioinformatics support. Thus, in addition to offering the full range of conventional tools for statistical analysis of biomedical data, the core now provides help with interpretation, management, and analysis of very large data sets (such as those generated through NGS deep sequencing of somatic variants, proteomics, single cell RNA sequencing, and ChipSeq). We anticipate that the integration of computational biology into our established Biostatistics Core, will result in the BBC exceeding the expectations of our user group, allowing investigators to explore powerful technologies that might previously have fallen outside their area of expertise.