# Resource Core

> **NIH NIH P30** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2021 · $309,685

## Abstract

PROJECT SUMMARY 
The Clinical and Community Resource Core will build on the strong foundation established by the MCRC Patient 
Resource Core at MUSC during the past 4 years. Since 2012 this core has served a local, national, international, 
and corporate base by providing a well phenotyped longitudinal cohort of predominantly African-American 
systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) patients and matched control data and 
banked biological samples. A recent formal survey of the research base indicated that needs are now exceeding 
the MCRC infrastructure. First, investigators need more intensive longitudinal follow-up of patients with specific 
disease sub-phenotypes such as scleroderma interstitial lung disease and lupus nephritis. Second, fresh 
biological specimens such as peripheral blood mononuclear cells and skin biopsies are needed in addition to 
banked specimens. Third, additional coordinator support is needed to facilitate efficient collection of fresh 
specimens and assist with regulatory requirements. Finally, translational scientists and junior investigators 
require consultation about engagement with the community, disease-specific study design and data 
interpretation, proposal feasibility analysis, and methods for flexibly adapting the services of the core to their 
needs. The Clinical and Community Resource Core (CCR Core) will flexibly expand on the services by providing 
the ability to more finely phenotype patients in the medical record in order to efficiently recruit patients for studies 
and more rigorously follow the longitudinal cohort during scheduled clinical visits. Automated reporting of specific 
SLE and SSc phenotypes will facilitate more efficient remote ordering of biological specimens. This automation 
will enable us to refocus coordinator resources to increase the percentage of clinic visits covered by the MCRC 
and fulfill requests by the research base. The core’s specific aims are to: 1) Maintain and flexibly expand the 
CCR Core with novel electronic health record (EHR) infrastructure to provide a well phenotyped, longitudinal 
cohort of SLE and SSc subjects and matched control volunteers to support the current and future needs of the 
research base; 2) Maintain and flexibly expand the CCR Core with novel EHR infrastructure to efficiently provide 
well phenotyped, banked and fresh biological specimens, both from within and beyond the existing longitudinal 
cohort, based on the ongoing and projected future needs of the research base; 3) Provide resources to link 
communities impacted by SSc and SLE and investigators in the research process, from project planning to 
dissemination and health promotion, by engaging with community members, community organizations and 
patient advocacy groups; and 4) Provide consultative and regulatory support to current and future projects of the 
research base. No other resource can provide fine phenotype data and samples from this unique population of 
pat...

## Key facts

- **NIH application ID:** 10254242
- **Project number:** 5P30AR072582-05
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** JAMES C OATES
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $309,685
- **Award type:** 5
- **Project period:** 2017-09-25 → 2022-09-22

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10254242

## Citation

> US National Institutes of Health, RePORTER application 10254242, Resource Core (5P30AR072582-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10254242. Licensed CC0.

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